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Fig. 5 | Molecular Cancer

Fig. 5

From: The molecular mechanism of LncRNA34a-mediated regulation of bone metastasis in hepatocellular carcinoma

Fig. 5

miR-34a inhibits TGF-β1-stimulated target gene expression and the proliferation and motility of hepatoma cells (n = 3). a-d miR-34a suppresses IL-11 and CTGF expression induced by TGF-β1 at both the mRNA (a and b) and protein level (c and d). The CCK-8 assay (e), wound-healing assay (f magnification × 40), and transwell assay (magnification: × 100) without (g) or with (h) Matrigel were performed to analyze the effect of miR-34a on the migration and invasion of SMMC-7721 and HCC-LM3 cells induced without or with TGF-β1. NC, negative control. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001

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