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Fig. 3 | Molecular Cancer

Fig. 3

From: Current perspectives on the immunosuppressive tumor microenvironment in hepatocellular carcinoma: challenges and opportunities

Fig. 3

Summary of potential candidates for Treg-targeted anti-tumor immunotherapy in HCC. Targets such as CCR4, PD-1, LAG3, TIM3 and GITR are primarily expressed on the membrane surface of Treg cells. Checkpoint inhibitors overcome T cell failure in HCC progression and restore the immunosuppressive state of the HCC microenvironment by blocking immunological checkpoint molecules. Abbreviations:CTLA4:cytotoxic T-lymphocyte-associated protein 4;PD-1:programmed cell death 1; TIM3: T cell immunoglobulin domain and mucin domain-3;LAG3: lymphocyte-activation gene 3;GITR:tumor necrosis factor receptor superfamily, member 18;ICOS: inducible T-cell co-stimulator;OX40: tumor necrosis factor receptor superfamily, member 4;CCR8:chemokine (C-C motif) receptor 8;CCR4:chemokine (C-C motif) receptor 4;GARP:glycoprotein-A repetitions predominant

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