Exosomes promote pre-metastatic niche formation in ovarian cancer

Table 1 Summary of ovarian cancer exosomal proteins involved with metastasis

Exosomal Proteins	Recipient cells	Role/Mechanism	Reference
Proteomic analysis: 2230 proteins were identified	N/A	Tumorigenesis and metastasis	[34]
ATF2, MTA1, ROCK1/2	HUVECs	Angiogenesis	[35]
GNA12, EPHA2 and COIA1	MSCs and ECs	Promote MSC and EC migration for metastasis	[36]
CD44	HPMCs	Tumor cell invasion.	[37]
RNA-binding protein LIN28	HEK293 cells	Increase HEK293 cell invasion and migration	[38]
Nanog	N/A	Tumor cell proliferation and invasion	[32, 33]

Abbreviations: ATF2 Activating transcription factor 2, MTA1 Metastasis-associated protein 1, ROCK Rho-Associated, Coiled-Coil Containing Protein Kinase, HUVECs Human umbilical vein endothelial cells, GNA12 Guanine nucleotide-binding protein subunit alpha-12, EPHA2 ephrin type-A receptor 2, COIA1 Collagen alpha-1 (XVIII) chain, MSCs Mesenchymal stem cells, ECs endothelial cells, HPMCs Human peritoneal mesothelial cells, LIN28 Lin-28 homolog A, HEK293 human embryonic kidney

ISSN: 1476-4598