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Fig. 2 | Molecular Cancer

Fig. 2

From: The emerging role of the piRNA/piwi complex in cancer

Fig. 2

piRNA/piwi protein function. a. At TGS level, the piRNA-proteins complex recruit silencing machinery components to bring repressive H3K9me3 marks to target DNA body and remove active H3K4me2 marks from promoter regions. In addition, piRNAs/piwi complex recruits DNMT, results in methylation at CpG sites in genic. b. At PTGS level, the piRNAs/piwi complex bind to targeted RNAs and impede their function by sequence complementary. c. piRNAs/piwi complex-protein interaction. The interaction between piRNAs/piwi and proteins alter the subcellular localization of proteins and facilitate the interaction of multiple proteins. Abbreviations: TGS: transcription gene silencing; PTGS: post-transcription gene silencing; H3K9me3: histone 3 lysine 9 trimethylation; H3K4me2: histone 3 lysine 4 dimethylation; DNMT: DNA methyltransferase

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