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Fig. 5 | Molecular Cancer

Fig. 5

From: WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1

Fig. 5

ETS1 played a tumor suppression role in HCC via the reversal of phenotypes mediated by WTAP. a Expression of ETS1 in HCC tumor and adjacent tissues from 29 pairs of HCC samples; b Expression of ETS1 mRNA was demonstrated based upon GEO datasets (GSE14520); c IHC scores of 32 pairs of HCC tissues in cohort1 based on ETS1 staining; d Representative IHC images of ETS1 staining in HCC tumor or adjacent tissues (scale bar, 100 μm; magnification, 200X and 400X); e Overall survival of HCC patients according to the level of ETS1 (data from TCGA); f and g CCK8 and colony formation assays were performed to examine the propagation ability of MHCC97H (f) and HCCLM3 (g), where ETS1 was knocked down or not, with bar charts indicating the colony numbers (right panel); h and i Rescue experiments were conducted to determine the influence of ETS1 silencing on WTAP knockdown cells (MHCC97H and HCCLM3), with bar charts showing colony numbers (right panel)

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