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Fig. 8 | Molecular Cancer

Fig. 8

From: Circular RNA circNHSL1 promotes gastric cancer progression through the miR-1306-3p/SIX1/vimentin axis

Fig. 8

CircNHSL1 promotes growth and metastasis of gastric cancer cells in vivo. a Images of subcutaneous xenograft tumors of MKN-28 cells. b Tumor weight of MKN-28 cells was shown. c Tumor volumes of MKN-28 cells measured every 3 days for 6 times were analyzed. d Image of subcutaneous xenograft tumors of SGC-7901 cells. e Tumor weight of SGC-7901 cells was shown. f Tumor volumes of SGC-7901 cells measured every 3 days for 6 times were analyzed. g Representative images of liver metastasis assay and HE staining of the liver of MKN-28 cells. Knockdown of circNHSL1 decreased the number of liver surface metastasis compared with negative control. h Representative images of liver metastasis assay and HE staining of the liver of SGC-7901 cells. Overexpression of circNHSL1 increased the number of liver surface metastasis compared with negative control. i-j Representative images of peritoneal metastasis assays. Knockdown of circNHSL1 decreased the number of peritoneal metastasis nodules compared with negative control (i), whereas overexpression of circNHSL1 increased the number of peritoneal metastasis nodules (j). **p < 0.01

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