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Fig. 1 | Molecular Cancer

Fig. 1

From: LncRNA PVT1 up-regulation is a poor prognosticator and serves as a therapeutic target in esophageal adenocarcinoma

Fig. 1

LncRNA PVT1 is amplified and overexpressed in EAC tumor tissues compared to Barrett’s epithelium and normal tissues. a. Analysis of PVT1 genomic alteration in TCGA dataset revealed PVT1 was amplified in over 20% of ESCA cases, and around 75% of ESCA cases containing both amplification and duplication (> 3 N) in total. b. Amplification of PVT1 gene in EAC is more common than that in ESCC. c. PVT1 expression levels significantly higher in amplification and duplication cases than that in LOH and diploid cases. d & e. Expressions PVT1 lncRNA and MYC mRNA were measured by qPCR and normalized to GAPDH in our own patient-cohort (156 cases)

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