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Fig. 4 | Molecular Cancer

Fig. 4

From: LncRNA PVT1 up-regulation is a poor prognosticator and serves as a therapeutic target in esophageal adenocarcinoma

Fig. 4

Suppression of PVT1 by ASOs reduces cancer stem cell (CSC) properties in EAC cells. a and b. Representative images (top) and the number (below) of tumorsphere formation showed that silencing of PVT1 by ASO4 and ASO5 suppressed sphere formation in both JHESO and OE19 cells. c. PVT1 ASO5 reduced the population of ALDH1+ cells (top: OE19; below: JHESO). JHESO and OE19 cells treated with PVT1 ASO5 at 10uM for 48 h and then labeling with ALDH1A1 using ALDH1 Labeling Kit. DEAB as negative control. Scale bar, 100 μm. Error bars, mean ± SEM. *, P < 0.05; **, P < 0.01

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