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Fig. 3 | Molecular Cancer

Fig. 3

From: METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer

Fig. 3

METTL3 promotes GC cell invasion and metastasis in vitro and in vivo. a-d Knockdown or overexpression of METTL3, decreased or increased, respectively, GC cells’ wound healing and invasion abilities in vitro. e-f Representative mice injected with modified METTL3 expressing BGC823 cells, downregulation of METTL3 decreased GC lung metastases. g-h Representative mice injected with modified METTL3 expressing MKN-28 cells, upregulation of METTL3 increased GC lung metastases. i-k Stomachs and livers from the orthotopic gastric cancer model. The stomach tumors were larger in METTL3-overexpressing group than those in the control. Overexpression of METTL3 facilitated the formation of liver metastasis. Scale bars: 100 μm. *p < 0.05, **p < 0.01, ***p < 0.001

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