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Fig. 4 | Molecular Cancer

Fig. 4

From: METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer

Fig. 4

ZMYM1 is a direct target of METTL3-mediated m6A modification. a-b RNA-sequencing identified differentially expressed genes in METTL3 knockdown GC cells when compared to the sh-NC control group. c-d m6A-sequencing identified the diminished m6A peaks in METTL3 knockdown GC cells when compared to the sh-NC control group. e The m6A consensus sequence motif was identified in BGC823 cells. f Distribution of m6A IP signal in mRNA transcripts in BGC823 cells. The m6A signal was enriched around the stop codon of mRNAs. g Filtering the diminished m6A peaks with the downregulated genes in sh-METTL3 BGC823 cells identified ZMYM1 as a direct target of METTL3. h Attenuation of METTL3 diminishes m6A modification of ZMYM1mRNA in BGC823 cells. A HuR binding site locates within the m6A modification region of ZMYM1

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Molecular Cancer

ISSN: 1476-4598