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Fig. 5 | Molecular Cancer

Fig. 5

From: METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer

Fig. 5

METTL3 maintains ZMYM1 expression in GC. a-b ZMYM1 transcripts upon METTL3 knockdown or overexpression as measured by qRT-PCR. c-d ZMYM1 protein levels upon METTL3 knockdown or overexpression as measured by western blotting analysis. e Co-expression of METTL3 and ZMYM1 in GC cells was determined by confocal immunofluorescent assay. Scale bars: 50 μm. f The mRNA levels of ZMYM1 in 60 GC tissues and paired normal tissues (Cohort 1) were determined by qRT-PCR. g METTL3 was positively correlated with ZMYM1 expression in 60 GC tissues (Cohort 1). h The nuclear colocalization of METTL3 and ZMYM1 in GC tissues were confirmed by confocal immunofluorescent assay. Scale bars: 100 μm. **p < 0.01

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