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Fig. 1 | Molecular Cancer

Fig. 1

From: Biogenesis, functions and clinical significance of circRNAs in gastric cancer

Fig. 1

Biogenesis of circRNAs. a liner mRNA: a single-stranded ribonucleic acids carrying genetic information; (b) lariat-driven circularization: this model requires the covalently binding between the splicing donor and splicing acceptor, thus forming an exon-containing lariat; (c) intron-pairing-driven circularization: intronic complementary base-pairs bring the adjacent two exons close together. The exons and introns are then cut away by spliceosome to form cirRNAs; (d) intron cyclization: intron is cleaved from the pre-mRNA to form a ciRNA

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