Table 1 Dysregulated circRNAs in GC

circPVT1

up-regulated

miR-125 family

Independent prognostic indicator; promotes cancer cell proliferation

187 GC tissue samples with various clinicopathologic features; MGC-803 and AGS GC cell lines

[75]

circRNA_100269

downregulated

miR-630

Inhibits cancer cell proliferation

112 GC tissue samples with various clinicopathologic features; AGS, MKN-28, MKN-45, BGC-823, MGC-803 and SGC-7901 GC cell lines

[76]

circNRIP1

up-regulated

miR-149-5p

Promotes cancer cell proliferation, invasion and migration

80 GC tissue samples with various clinicopathologic features; BGC-823, AGS, SGC-7901, MGC-803, MKN-45 and HGC-27 GC cell lines

[77]

circ-DONSON

up-regulated

–

Promotes cancer cell proliferation, invasion and migration

142 GC tissue samples; BGC-823, AGS, MGC-803, MKN74, HGC-27 and SGC-7901 GC cell lines

[78]

circRNA0047905

up-regulated

miR4516 miR1227-5p

Tumor promoter; potential therapy target

31 GC tissue samples; AGS GC cell line

[79]

circDLST

up-regulated

miR-502-5p

Promotes cancer cell proliferation, invasion and metastasis

396 GC tissue samples of various stages; MGC-803, BGC-823, SGC-7901, HGC-27, AGS, MKN-45 and MKN-28 GC cell lines

[80]

circ_0067997

up-regulated

miR-515-5p

Promotes cancer cell viability, proliferation and invasion

48 GC tissue samples with various clinicopathologic features; SGC-7901, MGC-803, BGC-823 and MKN28 GC cell lines

[81]

circCACTIN

up-regulated

miR-331-3p

Promotes GC cells migration, invasion and EMT

32 gastric adenocarcinoma tissue samples; GES1, BGC-823, MGC-803 and SGC-7901 GC cell lines

[82]

ciRS-7

up-regulated

miR-7

Promotes cancer cell proliferation

256 GC tissue samples (102 in training cohort and 154 in validation cohort) with various clinicopathologic features; MGC-803 and HGC-27 GC cell lines

[83]

circHIPK3

up-regulated

miR-124

miR-29b

Promotes cancer cell proliferation

63 GC tissue samples (28 infiltrative type samples and 35 expanding type samples); XGC-1 (infiltrative type) and XGC-2 (expanding type) GC cell lines

[73]

circPDSS1

up-regulated

miR-186-5p

Promotes cell cycle and proliferation, inhibits cell apoptosis

20 GC tissue samples; MGC-803, HGC-27, and BGC-823 GC cell lines

[84]

circFAT1

downregulated

miR-548 g

Inhibits cancer cell proliferation, invasion and migration

38 GC tissue samples with various clinicopathologic features; AGS,SGC-7901, BGC-823, MKN-28, MGC-803 and MKN-45 GC cell lines

[71]

circNF1

up-regulated

miR-16

Promotes cancer cell proliferation

23 GC tissue samples with various clinicopathologic features; MKN-28, NCI-N87, AGS, KATOIII, RF1, RF-48 GC cell lines

[85]

circYAP1

downregulated

miR-367-5p

Tumor suppressor, inhibits cell growth and invasion

80 GC tissue samples of various stages (13 of stage I, 25 of stage II, 38 with stage III and 4 of stage IV); HGC-27 GC cell line

[86]

hsa_circ_0000993

downregulated

miR-214-5p

Inhibits cellular migration, invasion and proliferation

Male patients tissue samples with stage III A primary GC (aged 59, 67 and 69 years, respectively); SGC-7901 and BGC-823 GC cell lines

[87]

circ-ZFR

downregulated

miR-107

miR-130a

Inhibits GC cell propagation, cell cycle and promotes apoptosis

48 GC tissue samples; AGS, AZ521, and HGC-27 GC cell lines

[88]

circHECTD1

up-regulated

miR-1256

Promotes glutaminolysis, proliferation, migration, and invasion of cancer cells; promotes autophagy; potential therapeutic target

GC tissue samples with various clinicopathologic features; BGC-823, MKN-45, HGC-27, AGS, MGC-803, and SGC-7901 GC cell lines

[89]

ciRS-133

up-regulated

miR-133

Aggravates tumour cachexia

Tissue and plasma samples of GC patients; SGC-7901 GC cell line

[90]

circAKT3

up-regulated*

miR-198

Enhances resistance to Cisplatin chemotherapy; therapeutic target

149 GC tissue samples (patients received CDDP treatment with/ without tumor relapse); SGC-7901 and BGC-823 GC cell lines and their CDDP-resistant strains SGC-7901CDDP and BGC-823CDDP

[91]