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Table 1 Dysregulated circRNAs in GC

From: Biogenesis, functions and clinical significance of circRNAs in gastric cancer

Name Dysregulation Sponge target Function Types of GC tissues and GC cell lines Ref.
circPVT1 up-regulated miR-125 family Independent prognostic indicator; promotes cancer cell proliferation 187 GC tissue samples with various clinicopathologic features; MGC-803 and AGS GC cell lines [75]
circRNA_100269 downregulated miR-630 Inhibits cancer cell proliferation 112 GC tissue samples with various clinicopathologic features; AGS, MKN-28, MKN-45, BGC-823, MGC-803 and SGC-7901 GC cell lines [76]
circNRIP1 up-regulated miR-149-5p Promotes cancer cell proliferation, invasion and migration 80 GC tissue samples with various clinicopathologic features; BGC-823, AGS, SGC-7901, MGC-803, MKN-45 and HGC-27 GC cell lines [77]
circ-DONSON up-regulated Promotes cancer cell proliferation, invasion and migration 142 GC tissue samples; BGC-823, AGS, MGC-803, MKN74, HGC-27 and SGC-7901 GC cell lines [78]
circRNA0047905 up-regulated miR4516 miR1227-5p Tumor promoter; potential therapy target 31 GC tissue samples; AGS GC cell line [79]
circDLST up-regulated miR-502-5p Promotes cancer cell proliferation, invasion and metastasis 396 GC tissue samples of various stages; MGC-803, BGC-823, SGC-7901, HGC-27, AGS, MKN-45 and MKN-28 GC cell lines [80]
circ_0067997 up-regulated miR-515-5p Promotes cancer cell viability, proliferation and invasion 48 GC tissue samples with various clinicopathologic features; SGC-7901, MGC-803, BGC-823 and MKN28 GC cell lines [81]
circCACTIN up-regulated miR-331-3p Promotes GC cells migration, invasion and EMT 32 gastric adenocarcinoma tissue samples; GES1, BGC-823, MGC-803 and SGC-7901 GC cell lines [82]
ciRS-7 up-regulated miR-7 Promotes cancer cell proliferation 256 GC tissue samples (102 in training cohort and 154 in validation cohort) with various clinicopathologic features; MGC-803 and HGC-27 GC cell lines [83]
circHIPK3 up-regulated miR-124
miR-29b
Promotes cancer cell proliferation 63 GC tissue samples (28 infiltrative type samples and 35 expanding type samples); XGC-1 (infiltrative type) and XGC-2 (expanding type) GC cell lines [73]
circPDSS1 up-regulated miR-186-5p Promotes cell cycle and proliferation, inhibits cell apoptosis 20 GC tissue samples; MGC-803, HGC-27, and BGC-823 GC cell lines [84]
circFAT1 downregulated miR-548 g Inhibits cancer cell proliferation, invasion and migration 38 GC tissue samples with various clinicopathologic features; AGS,SGC-7901, BGC-823, MKN-28, MGC-803 and MKN-45 GC cell lines [71]
circNF1 up-regulated miR-16 Promotes cancer cell proliferation 23 GC tissue samples with various clinicopathologic features; MKN-28, NCI-N87, AGS, KATOIII, RF1, RF-48 GC cell lines [85]
circYAP1 downregulated miR-367-5p Tumor suppressor, inhibits cell growth and invasion 80 GC tissue samples of various stages (13 of stage I, 25 of stage II, 38 with stage III and 4 of stage IV); HGC-27 GC cell line [86]
hsa_circ_0000993 downregulated miR-214-5p Inhibits cellular migration, invasion and proliferation Male patients tissue samples with stage III A primary GC (aged 59, 67 and 69 years, respectively); SGC-7901 and BGC-823 GC cell lines [87]
circ-ZFR downregulated miR-107
miR-130a
Inhibits GC cell propagation, cell cycle and promotes apoptosis 48 GC tissue samples; AGS, AZ521, and HGC-27 GC cell lines [88]
circHECTD1 up-regulated miR-1256 Promotes glutaminolysis, proliferation, migration, and invasion of cancer cells; promotes autophagy; potential therapeutic target GC tissue samples with various clinicopathologic features; BGC-823, MKN-45, HGC-27, AGS, MGC-803, and SGC-7901 GC cell lines [89]
ciRS-133 up-regulated miR-133 Aggravates tumour cachexia Tissue and plasma samples of GC patients; SGC-7901 GC cell line [90]
circAKT3 up-regulated* miR-198 Enhances resistance to Cisplatin chemotherapy; therapeutic target 149 GC tissue samples (patients received CDDP treatment with/ without tumor relapse); SGC-7901 and BGC-823 GC cell lines and their CDDP-resistant strains SGC-7901CDDP and BGC-823CDDP [91]
  1. *CircAKT3 is up-regulated in CDDP-resistant GC samples compared to CDDP-sensitive samples