Fig. 1
From: EGFR-TKI resistance promotes immune escape in lung cancer via increased PD-L1 expression
The expression of PD-L1 in NSCLC changes after acquisition of EGFR-TKIs resistance based on the patient biopsy specimens and TCGA datasets. a PD-L1 expression increased in a subgroup of EGFR-TKI resistant specimens. PD-L1 and c-MET expression status in paired specimens before and after acquired gefitnib resistance were measured by IHC staining. b PD-L1 expression status in EGFR-TKI resistant NSCLC specimens (N = 15). c and d The correlation coefficient between PD-L1 (CD274) and c-MET in lung adenocarcinoma and EGFR mutant subsets based on the TCGA datasets (Lung Adenocarcinoma, PanCancer Atlas and Provisional) and in EGFR-TKI resistant NSCLC specimens