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Table 3 The function of exosomal PD-L1 in tumor progression

From: The role of exosomal PD-L1 in tumor progression and immunotherapy

Type of tumor Source of exosomes Function References
Melanoma Plasma Suppress the function of CD8+ T cells and cause failure of anti-PD-1 therapy [16]
Breast cancer Tumor tissue Inhibit the secretion of granzyme B by cytotoxic lymphocytes to promote tumor growth [71]
Prostate cancer Tumor tissue Suppress the function of T cells in the draining lymph node and block anti-PD-L1 antibodies [70]
Head and neck squamous cell carcinomas Plasma Downregulate CD69 expression on effector T cells to inhibit anti-tumor responses [58]