Table 3 The function of exosomal PD-L1 in tumor progression
From: The role of exosomal PD-L1 in tumor progression and immunotherapy
Type of tumor | Source of exosomes | Function | References |
|---|---|---|---|
Melanoma | Plasma | Suppress the function of CD8+ T cells and cause failure of anti-PD-1 therapy | [16] |
Breast cancer | Tumor tissue | Inhibit the secretion of granzyme B by cytotoxic lymphocytes to promote tumor growth | [71] |
Prostate cancer | Tumor tissue | Suppress the function of T cells in the draining lymph node and block anti-PD-L1 antibodies | [70] |
Head and neck squamous cell carcinomas | Plasma | Downregulate CD69 expression on effector T cells to inhibit anti-tumor responses | [58] |