Fig. 7
From: Exosomal miR-21 regulates the TETs/PTENp1/PTEN pathway to promote hepatocellular carcinoma growth
miR-21 regulates the growth of HCC cells through the TETs/PTENp1/PTEN pathway. Hep3B cells were transfected with miR-21, miR-21 + TET1-O, miR-21 I (miR-21 inhibitors) + TET1 siRNA, TET1 siRNA, TET1-O + PTENp1 siRNA, or TET1-O. Cell proliferation was examined by BrdU assay (a), cell apoptosis was detected by flow cytometric analysis (b and c), and cell invasion was evaluated by Transwell Matrigel invasion assay (d and e; 200 × magnification). Each bar represents the mean ± SD determined from three samples (*P < 0.01, vs. control)