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Fig. 3 | Molecular Cancer

Fig. 3

From: ASPH-notch Axis guided Exosomal delivery of Prometastatic Secretome renders breast Cancer multi-organ metastasis

Fig. 3

Exosomes act as an outlet of MMPs; MMPs function as a direct executor for exosomes, contributing to ASPH mediated aggressive malignant phenotypes in breast cancer. (a-b) Invadopodia formation and ECM degradation/remodeling in response to inhibition of MMPs activities using GM6001. (c) 3-D invasion in response to GM6001. (d-e) Mammosphere formation in response to GM6001. (f) Transendothelial migration (intravasation/extravasation); (g) Invasion through basement membrane and subsequent mammosphere formation in response to GM6001. *p < 0.05; **p < 0.01; ***p < 0.001

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