Table 1 The function of the substance in HCC exosomes
From: The significance of exosomes in the development and treatment of hepatocellular carcinoma
Components | Functions | First author/s | Year | References |
|---|---|---|---|---|
Rab protein, GTPase, annexin | Membrane transport and fusion | CORDONNIER M | 2017 | [34] |
miRNA | ||||
miR-1247-3p | Promote lung migration of liver cancer | Fang T | 2018 | [77] |
miRNA-210 | Promotes angiogenesis | Lin XJ | 2018 | [81] |
miR-103 | Vascular permeability and metastasis | Fang JH | 2018 | [83] |
miR-23a-3p | Inhibits the function of T-cell | Liu J | 2019 | [99] |
miR-122 | Improve the treatment effect | Lou G | 2015 | [117] |
miR-335 | Novel therapeutic strategy | Wang F | 2018 | [118] |
microRNA-25-5p | Migration、Invasion | Liu H | 2018 | [122] |
miR-320a-PBX3 | Proliferation、metastasis | Zhang Z | 2017 | [123] |
miR-718 | Prediction the prognosis of HCC | Sugimachi K | 2015 | [124] |
miR-665 | Biomarker | Qu Z | 2017 | [125] |
HSP | ||||
HSP70, HSP60 and HSP90 | Diagnosis and treatment | CORDONNIER M | 2017 | [34] |
lncRNA HOTAIR | The release of exosomes | YANG L | 2019 | [45] |
RNA and DNA | Regulation cell genetics and epigenetics | ZHANG X | 2015 | [71] |
Vps4A | Tumor suppressor | Jin-xing Wei | 2015 | [76] |
lncRNA | ||||
lncRNA-ATB | Novel prognosis of biomarker and therapeutic targets | Lee YR | 2019 | [110] |
LUCAT1 and CASC9 | Biomarker | Gramantieri L | 2018 | [126] |
circRNA | ||||
circ-DB | Promote HCC growth and reduce DNA damage | Zhang H | 2019 | [79] |
circPTGR1 | Clinical stage and prognosis | Wang G | 2019 | [113] |