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Table 1 The function of the substance in HCC exosomes

From: The significance of exosomes in the development and treatment of hepatocellular carcinoma

ComponentsFunctionsFirst author/sYearReferences
Rab protein, GTPase, annexinMembrane transport and fusionCORDONNIER M2017[34]
 miR-1247-3pPromote lung migration of liver cancerFang T2018[77]
 miRNA-210Promotes angiogenesisLin XJ2018[81]
 miR-103Vascular permeability and metastasisFang JH2018[83]
 miR-23a-3pInhibits the function of T-cellLiu J2019[99]
 miR-122Improve the treatment effectLou G2015[117]
 miR-335Novel therapeutic strategyWang F2018[118]
 microRNA-25-5pMigration、InvasionLiu H2018[122]
 miR-320a-PBX3Proliferation、metastasisZhang Z2017[123]
 miR-718Prediction the prognosis of HCCSugimachi K2015[124]
 miR-665BiomarkerQu Z2017[125]
 HSP70, HSP60 and HSP90Diagnosis and treatmentCORDONNIER M2017[34]
 lncRNA HOTAIRThe release of exosomesYANG L2019[45]
 RNA and DNARegulation cell genetics and epigeneticsZHANG X2015[71]
 Vps4ATumor suppressorJin-xing Wei2015[76]
 lncRNA-ATBNovel prognosis of biomarker and therapeutic targetsLee YR2019[110]
 LUCAT1 and CASC9BiomarkerGramantieri L2018[126]
 circ-DBPromote HCC growth and reduce DNA damageZhang H2019[79]
 circPTGR1Clinical stage and prognosisWang G2019[113]
  1. HCC hepatocellular carcinoma, miR/miRNA micro ribonucleic acid, HSP heat shock proteins, circRNA Circular RNAs, lncRNA Long noncoding ribonucleic acid