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Table 1 MiRNAs and sorafenib resistance in HCC

From: The emerging role of microRNAs and long noncoding RNAs in drug resistance of hepatocellular carcinoma

MiRNAs Expression1 Pathway Reference
miR-21 up-regulated PTEN/Akt [49]
miR-93 up-regulated PTEN; CDKN1A [50]
miR-216a /217 up-regulated PTEN; SMAD7 [51]
miR-181a up-regulated RASSF1 [52]
miR-494 up-regulated PTEN [53]
mTOR [45]
miR-221 up-regulated caspase-3 [46]
miR-122 down-regulated IGF-1R [54]
IGF-1R; SRF; ADAM10 [55]
PDK4 [56]
SLC7a1 [57]
GALNT10 [58]
miR-34a down-regulated Bcl-2 [59]
miR-27b down-regulated P53 [60]
let-7 down-regulated BCL-XL [61]
miR-193b down-regulated MCL1 [62, 63]
miR-486 down-regulated CLDN10; CITRON [64]
miR-367-3p down-regulated Androgen receptor [65]
miR-338-3p down-regulated HIF-1α [43]
miR-137 down-regulated ANT2 [66]
miR-142-3p down-regulated ATG5/ATG16L1 [36]
miR-7 down-regulated TYRO3 [67]
  1. 1miRNAs either up-regulated or down-regulated in sorafenib resistant hepatocellular carcinoma cells
  2. Note: This table shows 18 miRNAs, their expression level and potential targets in sorafenib resistance of hepatocellular carcinoma