Table 1 MiRNAs and sorafenib resistance in HCC

miR-21

up-regulated

PTEN/Akt

[49]

miR-93

up-regulated

PTEN; CDKN1A

[50]

miR-216a /217

up-regulated

PTEN; SMAD7

[51]

miR-181a

up-regulated

RASSF1

[52]

miR-494

up-regulated

PTEN

[53]

mTOR

[45]

miR-221

up-regulated

caspase-3

[46]

miR-122

down-regulated

IGF-1R

[54]

IGF-1R; SRF; ADAM10

[55]

PDK4

[56]

SLC7a1

[57]

GALNT10

[58]

miR-34a

down-regulated

Bcl-2

[59]

miR-27b

down-regulated

P53

[60]

let-7

down-regulated

BCL-XL

[61]

miR-193b

down-regulated

MCL1

[62, 63]

miR-486

down-regulated

CLDN10; CITRON

[64]

miR-367-3p

down-regulated

Androgen receptor

[65]

miR-338-3p

down-regulated

HIF-1α

[43]

miR-137

down-regulated

ANT2

[66]

miR-142-3p

down-regulated

ATG5/ATG16L1

[36]

miR-7

down-regulated

TYRO3

[67]