The emerging role of microRNAs and long noncoding RNAs in drug resistance of hepatocellular carcinoma

Table 2 MiRNAs and adriamycin resistance in HCC

MiRNAs	Expression¹	Pathway	Reference
Let-7a	up-regulated	Caspase–3	[76]
miR-519d	up-regulated	CDKN1A/p21, PTEN, AKT3, TIMP2	[77]
miR-26a/b	down-regulated	ULK1	[78]
miR-26b	down-regulated	TAK1, TAB3	[79]
miR-520b	down-regulated	ATG7	[80]
miR-491-3p	down-regulated	Sp3/ABCB1	[81]
miR-122	down-regulated	MDR1	[82]
		ABCB1; ABCF2	[83]
		PKM2	[84]
miR-31	down-regulated	NDRG3	[85]
miR-223	down-regulated	ABCB1	[86]
miR-133a,miR-326	down-regulated	ABCC1	[87]
miR-101	down-regulated	EZH2	[88]
miR-101	down-regulated	Mcl-1	[89]
miR-199a-3p	down-regulated	mTOR, c-Met	[90]
miR-215	down-regulated	DHFR, TS	[91]
miR-145	down-regulated	Smad3	[92]
miR-503	down-regulated	MDR1, MRP, ERCC1, Bcl-2	[93]

¹miRNAs either up-regulated or down-regulated in adriamycin resistant hepatocellular carcinoma cells
Note: This table shows 17 miRNAs, their expression level and potential targets in adriamycin resistance of hepatocellular carcinoma