Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4

Table 2 Comparison of coinhibitory immune checkpoint receptors mentioned in manuscript

Receptor	LAG-3	TIM-3	TIGIT	VISTA	B7-H3	BTLA
Alternate name	CD223	HAVCR2	WUCAM/ Vstm3/ Vsig9	PD-1H/DD1α/ Gi24/Dies1/B7-H5	CD276	CD272
Chromosomal location	12p13.32	5q33.2	3q13.31	10q22.1	15q24.1	3q13.2
Function of ligand-receptor interaction	Co-inhibition	Co-inhibition	Co-inhibition	Co-inhibition	Co-inhibition or co-stimulation	Co-inhibition
Binding Partner	MHC-II, galectin-3, LSECtin, a-synuclein, FGL1	Galectin-9, Ceacam-1, HMGB-1, PtdSer	CD155, CD112	VSIG-3	Unknow	HVEM
Number of amino acids	498 amino acids	302 amino acids	244 amino acids	311 amino acids	316 amino acids	289 amino acids
Signaling motif	KIEELE motif	Tyrosine residues	ITT and ITIM	Unknow	Unknow	ITIM and ITSM
Receptor Expression	Activated T cells, B cells, Tregs, NK cells, DCs	Activated T cells, B cells, Tregs, DCs, NK cells, monocytes	T cells, NK cells	Myeloid cells, T cells	Activated T cells, NK cells, DCs, monocytes, tumor tissue	Mature B cells, T cells, Tregs, macrophages, DCs

ISSN: 1476-4598