Fig. 5

Plasma level of circGSK3β is a potential biomarker for ESCC. a The relative levels of circGSK3β in patients with healthy controls, benign lesions, and ESCC. b and c ROC curves showing plasma levels of circGSK3β in ESCC patients (b) and early stages of ESCC patients (c). d and e The comparison of ROC curves of circGSK3β, CEA and the combination of circGSK3β, CEA. f The pre-operative plasma level of circGSK3β and post-operation. g The comparison of percentage of patients with metastasis 10 months after the surgery in high vs. low circGSK3β level. ns., not significant. * P < 0.05; ** P < 0.01; and *** P < 0.001