Table 1 The roles of RNA m6A in gastrointestinal tract cancers
The roles of RNA m6A in gastrointestinal tract cancers | ||||
|---|---|---|---|---|
cancer | m6A Regulators | Role in cancer | Biological function | Mechanism |
Liver cancer | METTL14 [32] | Suppressor gene | Suppresses HCC metastasis | Promotes pri-mia-126 processing |
METTL3 [33] | Oncogene | Promotes HCC growth | Promotes SOCS2 degradation | |
Gastric cancer | METTL3 [34] | Oncogene | Promotes GC growth | down-regulation of METTL3 leads to inactivation of the AKT signaling pathway |
m6A [35] | Suppressor | Suppresses GC cell proliferation and invasiveness | Inhibition of m6A activates Wnt and PI3K-AKT signaling | |
METTL3 [36] | Oncogene | Promotes GC growth and metastasis | METTL3 knockdown reduced α-smooth muscle actin | |
colorectal cancer | METTL3 [37] | Oncogene | Promotes CRC growth | prevent SOX2 mRNA degradation |
METTL3 [38] | Suppressor gene | Suppresses CRC proliferation, migration and invasion | activates p38/ERK pathways | |
YTHDF1 [39] | Oncogene | – | c-Myc-driven YTHDF1 axis significance | |
YTHDF1 [40] | Oncogene | – | YTHDF1 inhibits the activity of Wnt/beta-catenin pathway | |
pancreatic cancer | YTHDF2 [41] | Oncogene | Promotes the migration and proliferation | YTHDF2 may regulate EMT through YAP signaling. |
FTO [42] | Oncogene | Promotes the migration and proliferation | – | |