Skip to main content

Table 1 The roles of RNA m6A in gastrointestinal tract cancers

From: N6-methyladenosine (m6A) RNA modification in gastrointestinal tract cancers: roles, mechanisms, and applications

The roles of RNA m6A in gastrointestinal tract cancers
cancerm6A RegulatorsRole in cancerBiological functionMechanism
Liver cancerMETTL14 [32]Suppressor geneSuppresses HCC metastasisPromotes pri-mia-126 processing
METTL3 [33]OncogenePromotes HCC growthPromotes SOCS2 degradation
Gastric cancerMETTL3 [34]OncogenePromotes GC growthdown-regulation of METTL3 leads to inactivation of the AKT signaling pathway
m6A [35]SuppressorSuppresses GC cell proliferation and invasivenessInhibition of m6A activates Wnt and PI3K-AKT signaling
METTL3 [36]OncogenePromotes GC growth and metastasisMETTL3 knockdown reduced α-smooth muscle actin
colorectal cancerMETTL3 [37]OncogenePromotes CRC growthprevent SOX2 mRNA degradation
METTL3 [38]Suppressor geneSuppresses CRC proliferation, migration and invasionactivates p38/ERK pathways
YTHDF1 [39]Oncogenec-Myc-driven YTHDF1 axis significance
YTHDF1 [40]OncogeneYTHDF1 inhibits the activity of Wnt/beta-catenin pathway
pancreatic cancerYTHDF2 [41]OncogenePromotes the migration and proliferationYTHDF2 may regulate EMT through YAP signaling.
FTO [42]OncogenePromotes the migration and proliferation