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Table 1 The roles of RNA m6A in gastrointestinal tract cancers

From: N6-methyladenosine (m6A) RNA modification in gastrointestinal tract cancers: roles, mechanisms, and applications

The roles of RNA m6A in gastrointestinal tract cancers
cancer m6A Regulators Role in cancer Biological function Mechanism
Liver cancer METTL14 [32] Suppressor gene Suppresses HCC metastasis Promotes pri-mia-126 processing
METTL3 [33] Oncogene Promotes HCC growth Promotes SOCS2 degradation
Gastric cancer METTL3 [34] Oncogene Promotes GC growth down-regulation of METTL3 leads to inactivation of the AKT signaling pathway
m6A [35] Suppressor Suppresses GC cell proliferation and invasiveness Inhibition of m6A activates Wnt and PI3K-AKT signaling
METTL3 [36] Oncogene Promotes GC growth and metastasis METTL3 knockdown reduced α-smooth muscle actin
colorectal cancer METTL3 [37] Oncogene Promotes CRC growth prevent SOX2 mRNA degradation
METTL3 [38] Suppressor gene Suppresses CRC proliferation, migration and invasion activates p38/ERK pathways
YTHDF1 [39] Oncogene c-Myc-driven YTHDF1 axis significance
YTHDF1 [40] Oncogene YTHDF1 inhibits the activity of Wnt/beta-catenin pathway
pancreatic cancer YTHDF2 [41] Oncogene Promotes the migration and proliferation YTHDF2 may regulate EMT through YAP signaling.
FTO [42] Oncogene Promotes the migration and proliferation