Table 1 Role of MRN complex in tumorigenesis
From: MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment
Cancer type | Molecules | Results | Year | Ref |
|---|---|---|---|---|
B cell lymphoma | MRE11 | x MRE11 promotes tumorigenesis by facilitating resistance to replication stress. | 2017 | [98] |
Breast Cancer | MRN | ✓ MRE11, RAD50 and NBS1 were genes with moderate penetrance. | 2016 | [68] |
MRN | ✓Mutations in MRN contribute to increased cancer risk. | 2013 | [70] | |
MRN | x MRN complex genes did not confer any appreciable risks. | 2017 | [74] | |
MRE11 | ✓ Defect in MRE11 function promotes progression of mammary hyperplasia into invasive, metastatic cancer. | 2013 | [69] | |
MRE11 | ✓ MRE11 variant was associated with increased risk of breast cancer. | 2018 | [73] | |
MRE11, RAD50 | ✓ MRE11 and RAD50 were moderate-susceptibility genes for breast cancer. | 2015 | [92] | |
MRE11 | x Variants of MRE11 gene did not constitute a risk factor. | 2018 | [96] | |
NBS1 | ✓ NBS1 variant 923T>C might be a risk factor for breast cancer development. | 2016 | [72] | |
Burkitt lymphoma | RAD50 | ✓ RAD50 mutations were identified in Burkitt lymphoma. | 2017 | [83] |
Endometrial carcinoma | RAD50 | ✓ RAD50 mutation was frequently detected. | 2017 | [82] |
Gastric cancer | MRE11 | ✓ Low expression of MRE11 was associated with gastric cancer. | 2019 | [78] |
Glioma | MRE11, NBS1 | ✓ NBS1 and MRE11 variants were associated with increased risk | 2015 | [77] |
HBOC | MRN | ✓ MRN mutations were detected in HBOC patients. | 2014 | [93] |
RAD50 | ✓ Mutations in RAD50 was implicated in cancer predisposition. | 2017 | [71] | |
Hepatic carcinoma | MRE11 | ✓ Expression of MRE11 was lower in chemical reagent induced hepatic carcinoma. | 2015 | [79] |
Hepatic carcinoma | RAD50 | ✓ Mutations in RAD50 lead to liver tumorigenesis. | 2014 | [84] |
IHC | NBS1 | ✓ NBS1 variants were associated with cancer susceptibility for IHC. | 2013 | [87] |
Lung cancer | NBS1 | ✓ Variants of NBS1 were related with increased risk for lung cancer. | 2015 | [86] |
NBS1 | ✓ Functional polymorphisms of NBS1 were related with increased risk for lung cancer. | 2014 | [90] | |
Myeloid leukemia | RAD50 | ✓ Alteration of RAD50 was found in myeloid leukemia. | 2019 | [81] |
Neuroblastoma | MRE11 | ✓ Alterations in MRE11 was frequent in neuroblastoma. | 2017 | [80] |
NPC | NBS1 | ✓ Polymorphism of NBS1 is associated with development and status of NPC. | 2011 | [89] |
Ovarian Cancer | MRN | ✓ Lack of MRN detection occurred frequently in ovarian cancer. | 2017 | [76] |
MRE11, RAD50 | ✓ Pathogenic or likely pathogenic variants were detected in patients. | 2018 | [75] | |
MRE11 | ✓ Low expression of MRE11 was associated with cancer developments. | 2014 | [94] | |
RAD50 | x RAD50 was ruled out as a risk factor. | 2017 | [91] | |
Prostate cancer | NBS1 | ✓ Variants of NBS1 were prevalent in familial prostate cancer. | 2018 | [85] |
Renal cell carcinoma | NBS1 | ✓ Mutation in NBS1 functional domains was related with susceptibility to renal cell carcinoma. | 2015 | [88] |