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Fig. 3 | Molecular Cancer

Fig. 3

From: Extracellular vesicles of carcinoma-associated fibroblasts creates a pre-metastatic niche in the lung through activating fibroblasts

Fig. 3

Comparison of proteins between CAF-A1/A2 EVs and SACC-LM EVs by ITRAQ. a Overexpressed proteins in the two comparison groups (CAF-A1 EVs vs. SACC-LM EVs, CAF-A2 EVs vs. SACC-LM EVs). b Heat map of the 66 proteins overexpressed in both CAF-A1 and CAF-A2 EVs, compared with SACC-LM EVs. c Biological Process enrichment of the 66 overexpressed proteins. d TSP1, LOXL2, and MMP2 expression in the EVs from SACC-LM, CAF-A1 and CAF-A2 cells by western blot. e TSP1 was downregulated in CAF-A1/A2 EVs by TSP1-specific siRNA transfection. Expression of p-Smad3 in LFs treated with CAF-A1/A2 EVs-NC, CAF-A1/A2 EVs-siTSP1–1, and CAF-A1/A2 EVs-siTSP1–2 assessed by western blot and immunofluorescent staining. Scale bar = 100 μm. ** P < 0.01

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Molecular Cancer

ISSN: 1476-4598