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Fig. 1 | Molecular Cancer

Fig. 1

From: KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3

Fig. 1

KIAA1429 predicts poor prognosis of HCC patients and is required for cell proliferation and invasion. a KIAA1429 expression in 70 pairs of HCC tissues and adjacent normal tissues from WCH dataset by using qPCR. b-c Kaplan-Meier analyses of the correlations between KIAA1429 expression and overall survival or disease-free survival of 70 HCC patients. The median expression level was used as the cutoff. Values are expressed as the median with interquartile range. d-e, EdU immunofluorescence staining assays for SK-Hep1 and HCCLM3 cells transfected with KIAA1429 siRNAs or the control. Scale bars = 100 μm. f and g, Cell apoptosis was measured by FITC-Annexin V and PI staining in SK-Hep1 and HCCLM3 cells transfected with KIAA1429 siRNAs or the control, followed by flow cytometric analysis. h and i, Transwell invasion assays for SK-Hep1 and HCCLM3 cells transfected with KIAA1429 siRNAs or the control. Scale bars = 100 μm. Data are presented as mean ± SEM. **P < 0.01, ***P < 0.001

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