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Fig. 6 | Molecular Cancer

Fig. 6

From: Long noncoding RNA LCAT1 functions as a ceRNA to regulate RAC1 function by sponging miR-4715-5p in lung cancer

Fig. 6

RAC1 is a target of miR-4715-5p and indirectly regulated by LCAT1. a GSEA enrichment analysis of miR-4715-5p potential targets. b Luciferase activity assay in A549 cells transfected with plasmid containing RAC1 3’UTR (wildtype, Wt or mutant, Mut) and miR-4715-5p mimics or control miRNA. c RAC1 expression in lung cancer cells transfected with control miRNA or miR-4715-5p mimics. d Western blot analysis of RAC1 expression in the lung cancer cells transfected with control miRNA or miR-4715-5p mimics. e, f RAC1 mRNA and protein levels in lung cancer cells following LCAT1 knockdown. g RAC1 expression in lung tumor tissues and adjacent normal tissues from TCGA cohort. h, i Kaplan-Meier survival analysis of overall survival and progression-free survival time in lung cancer patients based on RAC1 expression. j Relationship between LCAT1 expression, RAC1 expression and RAC1 copy number variation (CNV)

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Molecular Cancer

ISSN: 1476-4598