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Fig. 1 | Molecular Cancer

Fig. 1

From: N6-methyladenosine induced miR-143-3p promotes the brain metastasis of lung cancer via regulation of VASH1

Fig. 1

miR-143-3p is correlated with the BM and progression of lung cancer. a The miRNA expression profiles in 6 matched pairs of primary lung cancer and BM tissues were analysed by use of the mercury LNA™ microRNA Array. The miRNAs with variation fold greater than 2 were showed. b The expression of miR-27b, miR-143-3p, miR-145, and miR-192 in lung cancer patients with (n = 10) or without (n = 10) BM was checked by in situ hybridization (ISH). c The expression of carcinoembryonic antigen (CEA) in miR-143-3p + (n = 38) or miR-143-3p- (n = 28) lung cancer patients. d The diameter of tumor in miR-143-3p + (n = 38) or miR-143-3p- (n = 28) lung cancer patients when diagnosis. e Kaplan-Meier survival curves of OS based on miR-143-3p expression in lung cancer patients (data from online bioinformatics tool Kaplan-Meier plotter). The log-rank test was used to compare differences between the two groups. f Kaplan-Meier survival curves of OS based on miR-143-3p expression in lung cancer patients (data from TCGA database). The log-rank test was used to compare differences between the two groups. Scale bar = 200 μm

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