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Table 1 Functions of m6A regulators in RNA metabolism.

From: Functions of N6-methyladenosine and its role in cancer

TypeRegulatorFunctionReference
m6A writerMETTL3catalyzes m6A modification[13, 14]
METTL14helps METTL3 to recognize the subtract[13, 14]
METTL16catalyzes m6A modification[15]
RBM15binds the m6A complex and recruit it to special RNA site[16, 17]
VIRMArecruits the m6A complex to the special RNA site and interacts with polyadenylation cleavage factors CPSF5 and CPSF6[18]
WTAPcontributes to the localization of METTL3-METTL14 heterodimer to the nuclear speckle[19]
ZC3H13bridges WTAP to the mRNA-binding factor Nito[20]
m6A eraserALKBH5removes m6A modification[21]
FTOremoves m6A modification[22]
m6A readerEIF3enhances mRNA translation[23]
HNRNPA2B1mediates mRNA splicing and primary microRNA processing[24]
HNRNPCmediates mRNA splicing[25]
IGF2BPsenhances mRNA stability and storage[26]
YTHDC1contributes to RNA splicing and export[27, 28]
YTHDC2enhances the translation of target RNA and reduces the abundance of target RNA[29]
YTHDF1enhances mRNA translation[30]
YTHDF2promotes mRNA degradation[31, 32]
YTHDF3enhances translation and degradation by interacting with YTHDF1 and YTHDF2[33, 34]