Functions of N6-methyladenosine and its role in cancer

Table 1 Functions of m6A regulators in RNA metabolism.

Type	Regulator	Function	Reference
m6A writer	METTL3	catalyzes m6A modification	[13, 14]
	METTL14	helps METTL3 to recognize the subtract	[13, 14]
	METTL16	catalyzes m6A modification	[15]
	RBM15	binds the m6A complex and recruit it to special RNA site	[16, 17]
	VIRMA	recruits the m6A complex to the special RNA site and interacts with polyadenylation cleavage factors CPSF5 and CPSF6	[18]
	WTAP	contributes to the localization of METTL3-METTL14 heterodimer to the nuclear speckle	[19]
	ZC3H13	bridges WTAP to the mRNA-binding factor Nito	[20]
m6A eraser	ALKBH5	removes m6A modification	[21]
m6A eraser	FTO	removes m6A modification	[22]
m6A reader	EIF3	enhances mRNA translation	[23]
	HNRNPA2B1	mediates mRNA splicing and primary microRNA processing	[24]
	HNRNPC	mediates mRNA splicing	[25]
	IGF2BPs	enhances mRNA stability and storage	[26]
	YTHDC1	contributes to RNA splicing and export	[27, 28]
	YTHDC2	enhances the translation of target RNA and reduces the abundance of target RNA	[29]
	YTHDF1	enhances mRNA translation	[30]
	YTHDF2	promotes mRNA degradation	[31, 32]
	YTHDF3	enhances translation and degradation by interacting with YTHDF1 and YTHDF2	[33, 34]

ISSN: 1476-4598