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Table 2 Roles of m6A enzymes in cancer

From: Functions of N6-methyladenosine and its role in cancer

cancer type

enzyme

target RNA

effect of enzyme on target RNA

role of m6A in cancer

reference

AML

METTL3

c-MYC, BCL2, PTEN

translation

inhibits cell differentiation and apoptosis, promotes leukemia progression

[118]

METTL3

SP1

translation

promotes cell proliferation and inhibits cell differentiation

[119]

Breast cancer

ALKBH5

NANOG

stabilization

inhibits tumor formation and breast cancer stem cell population

[120]

FTO

BNIP3

degradation

inhibits breast cancer cell proliferation, colony formation and metastasis

[121]

METTL3

HBXIP

expression

enhances proliferation, invasion and metastisis and inhibits apoptosis

[122]

CSCC

FTO

β-catenin

expression

enhances the chemo-radiotherapy resistance

[123]

GSC

ALKBH5

FOXM1

expression

impairs proliferation and tumorigenicity

[21]

METTL3

SOX2

stability

enhances of neurosphere formation

[124]

HCC

METTL14

miRNA 126

splicing

inhibits the migration and invasiveness of HepG2 cells and restrains tumor metastasis

[125]

LUSC

FTO

MZF1

stability

inhibits proliferation and invasion and increases apoptosis

[22]

Ovarian cancer

METTL3

AXL

translation

promotes growth and invasion of ovarian tumors

[126]

Pancreatic cancer

ALKBH5

KCNK15-AS1

expression

promotes migration and invasion

[127]

Renal cell carcinoma

FTO

PGC-1α

stability

enhances cell growth and facilitates apoptosis

[128]

  1. LUSC: lung squamous cell carcinoma; AML: acute myeloid leukemia; GSC: glioblastoma stem-like cell; HCC: human hepatocellular carcinoma; CSCC: cervical squamous cell carcinoma