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Table 2 Roles of m6A enzymes in cancer

From: Functions of N6-methyladenosine and its role in cancer

cancer typeenzymetarget RNAeffect of enzyme on target RNArole of m6A in cancerreference
AMLMETTL3c-MYC, BCL2, PTENtranslationinhibits cell differentiation and apoptosis, promotes leukemia progression[118]
METTL3SP1translationpromotes cell proliferation and inhibits cell differentiation[119]
Breast cancerALKBH5NANOGstabilizationinhibits tumor formation and breast cancer stem cell population[120]
FTOBNIP3degradationinhibits breast cancer cell proliferation, colony formation and metastasis[121]
METTL3HBXIPexpressionenhances proliferation, invasion and metastisis and inhibits apoptosis[122]
CSCCFTOβ-cateninexpressionenhances the chemo-radiotherapy resistance[123]
GSCALKBH5FOXM1expressionimpairs proliferation and tumorigenicity[21]
METTL3SOX2stabilityenhances of neurosphere formation[124]
HCCMETTL14miRNA 126splicinginhibits the migration and invasiveness of HepG2 cells and restrains tumor metastasis[125]
LUSCFTOMZF1stabilityinhibits proliferation and invasion and increases apoptosis[22]
Ovarian cancerMETTL3AXLtranslationpromotes growth and invasion of ovarian tumors[126]
Pancreatic cancerALKBH5KCNK15-AS1expressionpromotes migration and invasion[127]
Renal cell carcinomaFTOPGC-1αstabilityenhances cell growth and facilitates apoptosis[128]
  1. LUSC: lung squamous cell carcinoma; AML: acute myeloid leukemia; GSC: glioblastoma stem-like cell; HCC: human hepatocellular carcinoma; CSCC: cervical squamous cell carcinoma