From: Functions of N6-methyladenosine and its role in cancer
cancer type | enzyme | target RNA | effect of enzyme on target RNA | role of m6A in cancer | reference |
---|---|---|---|---|---|
AML | METTL3 | c-MYC, BCL2, PTEN | translation | inhibits cell differentiation and apoptosis, promotes leukemia progression | [118] |
METTL3 | SP1 | translation | promotes cell proliferation and inhibits cell differentiation | [119] | |
Breast cancer | ALKBH5 | NANOG | stabilization | inhibits tumor formation and breast cancer stem cell population | [120] |
FTO | BNIP3 | degradation | inhibits breast cancer cell proliferation, colony formation and metastasis | [121] | |
METTL3 | HBXIP | expression | enhances proliferation, invasion and metastisis and inhibits apoptosis | [122] | |
CSCC | FTO | β-catenin | expression | enhances the chemo-radiotherapy resistance | [123] |
GSC | ALKBH5 | FOXM1 | expression | impairs proliferation and tumorigenicity | [21] |
METTL3 | SOX2 | stability | enhances of neurosphere formation | [124] | |
HCC | METTL14 | miRNA 126 | splicing | inhibits the migration and invasiveness of HepG2 cells and restrains tumor metastasis | [125] |
LUSC | FTO | MZF1 | stability | inhibits proliferation and invasion and increases apoptosis | [22] |
Ovarian cancer | METTL3 | AXL | translation | promotes growth and invasion of ovarian tumors | [126] |
Pancreatic cancer | ALKBH5 | KCNK15-AS1 | expression | promotes migration and invasion | [127] |
Renal cell carcinoma | FTO | PGC-1α | stability | enhances cell growth and facilitates apoptosis | [128] |