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Table 3 Roles of m6A in RNA metabolism and cancer

From: Functions of N6-methyladenosine and its role in cancer

tumor typestarget RNAfunction of target RNAaberrant expression of m6A enzymesreadersfunction of readerschange of target RNA levelreference
AMLMYC, MYBoncogenicMETTL14↑EIF3translation[58]
Bladder cancerCDCP1oncogenicMETTL3↑YTHDF1translation[109]
Colorectal carcinomaSOX2oncogenicMETTL3↑, IGF2BP2↑IGF2BP2stabilization[80]
Endometrial cancermTORC2oncogenicMETTL3↓YTHDF2degradation[110]
PHLPP2antitumorMETTL3↓YTHDF1translation[110]
Gastric cancerHDGFoncogenicMETTL3↑IGF2BP3stabilization[111]
HCCEGFRoncogenicYTHDF2↓YTHDF2degradation[112]
SOCS2antitumorMETTL3↑YTHDF2degradation[113]
LeukemiaMERTK,BCL-2oncogenicFTO↑YTHDF2degradation[114]
Liver cancerSnailoncogenicMETTL3↑YTHDF1translation[115]
Lung cancerBRD4, EGFR,TAZoncogenicMETTL3↑EIF3translation[43, 44]
Ovarian cancerSRFoncogenicIGF2BP1↑IGF2BP1stabilization[78, 100, 101]
  1. HCC: human hepatocellular carcinoma; AML: acute myeloid leukemia