Table 1 Effect of miRNAs, LNCRNAs and Circular RNAs on molecular mechanisms of FOXP family proteins and their related genes in several cancers
| Â | Expression Level | Related gene | Function | Molecular mechanism | cancer | cell line | References |
|---|---|---|---|---|---|---|---|
Tumor Suppressor miRNAs | |||||||
 microRNA-181d-5p | down | FOXP1↓ | cell proliferation↓ metastasis↓ EMT↓ | miR-181d-5p-FOXP1 feedback loop | Osteosarcoma | MG63, SaOS2 U2OS, HOS | 1 |
 microRNA-374b-5p | down | FOXP1 ↓ | cell proliferation↓ migration↓ EMT↓ cisplatin sensitivity↑ | miR-374b-5p-FOXP1 feedback loop | Ovarian | SKOV3, 3AO A2780, OVCAR3 | 2 |
 microRNA-122 | down | FOXP1 ↓ | apoptosis ↑ | crosstalk | HCC | HepG2 | 3 |
 microRNA-150 | down | FOXP1 ↓ | cell proliferation ↓ | Myc↑ → miR-150↓ → Foxp1↑ | trnasformation of FL to DLBCL | patient sample | 4 |
 microRNA-504 | down | FOXP1 ↓ | cell proliferation↓ cell cycle arrest↑ apoptosis↑ | FOXP1 as a direct target of miR-504 | Gliomas | U87, U373, U251,T98G, LN18, LN229, SF295 | 5 |
 microRNA-9 | down | FOXP1 ↓ | tumorgenity | ΔEGFR/Ras/PI3K/AKT axis → miR-9↓ → FOXP1↑ | Glioblastoma | U87, U373 ΔEGFR cells | 6 |
 microRNA-34a | down | FOXP1 ↓ | malignant transformation ↓ | Myc↑ → miR-34a↓ → Foxp1↑ | Gastric DLBCL | U2932 | 7 |
 microRNA-376-a | down | FOXP2 ↓ | cell proliferation↓ apoptosis↑ | cyclin D2↓, cyclin A↓, Bax↑ and Bcl-2↓. | Lymphoma | JeKo-1 | 8 |
 microRNA-139 | down | FOXP2 ↓ | proliferation↓migration↓ | FOXP2 is a direct target of miR-139 | Osteosarcoma | SAOS-2 MG63 | 9 |
 microRNA-7 microRNA-155 |  | induced by FOXP3 | Transformation of the healthy breast epithelium to a cancerous phenotype↓ | FOXP3 and FOXP3-regulated microRNAs → SATB1↓ | Breast | BT549 | 12 |
 microRNA-146 |  | Induced by FOXP3 | proliferation↓ apoptosis↑ | FOXP3 → miR-146a/b↑→ NF-κB activation↓ by repressing Irak1 and Traf6 | Breast | T47D, BT474, MDA-MB-468 | 10 |
 microRNA-146 |  | induced by FOXP3 | apoptosis ↑ during tumor initiation tumor supression | FOXP3 → miR-146a/b↑→ NF-κB activation↓ by repressing Irak1 and Traf6 | Prostate | PC3 DU145 LNCaP | 11 |
 microRNA-338-3p | down | FOXP4 ↓ | proliferation↓ cell cycle arrest↑ | miR-338-3p could directly target FOXP4 | HCC | HepG2 Hep3B,QGY7703 | 13 |
 microRNA-491-5p | down | FOXP4 ↓ | proliferation↓ migration↓ invasion↓ apoptosis↑ | FOXP4 is a target of miR-491-5p | Osteosarcoma | SAOS-2 MG63,U-2OS | 14 |
 microRNA-138 | down | FOXP4↓ | growth↓ invasion↓ | miR-138 was the upstream regulator of FOXP4 | NSCLC | SK-MES-1, A549, H460, SPC-A1 | 15.1/15.2 |
Oncogenic miRNAs | |||||||
 microRNA-92a | up | FOXP1↓ | cell proliferation↑cell cycle progression↑ tumor growth↑ | FOXP1 was identified as a functional downstream target of miR-92a | OSCC | HSC3, OC3, SSC25 Tca-8113 | 16 |
 microRNA-504 | up (stage lll, lV) | FOXP1↓ | invasion ↑ metastasis ↑ | CTGF → miR-504↓ → FOXP1↑ | OSCC | SAS | 18 |
 microRNA-19a | up | FOXP1↓ | cell viability↑ colony formation↑ migration↑ invasion↑ | miR-19a↑ → FOXP1, TP53INP1, TNFAIP3, and TUSC2↓ | Lung | LK79 | 17 |
 microRNA-196b | up | FOXP2 ↓ | migration ↑ invasion ↑ | miR 196b could directly bind to the 3'UTR of FOXP2mRNA | HCC | HCCLM3, Huh7 Hep3B, MHCC97H | 19 |
 microRNA-23a | up | FOXP2 ↓ | proliferation↑ invasion↑ | miR-23a directly targets FOXP2 | PDAC | Aspc-1, Capan-2, Bxpc-3, Panc-1, MIA-Paca-2, SW1990 | 20 |
 microRNA-190 | up | FOXP2↓ | invasion ↑ migration ↑proliferation↑ | the direct target regulation of miR-190 to FOXP2 | Gastric | GC tissue | 21 |
 microRNA-155 | up | induced by FOXP3 | Tumor initiaion | FOXP3 → BRCA1↓ → miR-155↑ | Breast | Breast tissue | 22 |
LNCRNAs | |||||||
 MALAT1 | up | FOXP1↑ | proliferatin↑ cell grotwh ↑ apoptosis↓ G1/S phase ↓ | MALAT1↑ → Foxp1↑ through sponging mir-509-5p | multiple myeloma | MM.1S, OPM-2, NCL-H929, U266, RPMI-8226 | 23 |
 SNHG12 | up | FOXP1↑ | proliferation↑ apoptosis↓ cell growth↑ migration↑ | SNHG12/miR-101-3p/FOXP1 axis | Glioma | U87 U251, A172, SHG44 | 24 |
 UFC1 | up | FOXP3↑ | cell proliferation↑ migration↑ invasion↑ apoptosis↓ | E2F1-linc-UFC1/miR-34a/FOXP3 axix | Cervical | Hela sila | 25 |
 7SL | up | inhibited by FOXP3 | tumor growth | FOXP3 → 7SL↓ → P53↑ feedback loop | Breast | MCF-7 MCF10A | 26 |
 MFI2 | up | FOXP4↑ | proliferation↑ apoptosis↓ migration↑ invasion↑ | correlation between MFI2 expression and FOXP4 expression | Osteosarcoma | MG63 SAOS-2 | 27 |
 Circular RNAs |  |  |  |  |  |  |  |
 Circ-SHKBP1 | up | FOXP1↑ FOXP2↑ | angiogenesis ↑ | circ-SHKBP1 → miR-544a/miR-379 ↓ → FOXP1 FOXP2↑→ AGGF1↑→ PI3K/AKT ERK1/2 ↑ | Malignant gliomas | GECs | 28 |
 CircRNAZNF609 | up | FOXP4↑ | proliferaion↑ invasion↑ | CircRNAZNF609↑ → FOXP4↑ by sponging miR-138-5p | Renal carcinoma | A-498, ACHN | 29 |
 CircMYO9B | up | FOXP4↑ | proliferaion↑ invasion↑ migration↑ | CircMYO9B↑ → FOXP4↑ by sponging miR-4316 | Breast | MCF-7 MDA-MB-231 | 30 |