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Fig. 2 | Molecular Cancer

Fig. 2

From: The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer

Fig. 2

Model structure showing the interactions stabilizing BAY-1082439/P-gp and BAY-1082439/BCRP complexes. a Domains and positions of P-gp binding with BAY-1082439. b Structures showing the surface of BAY-1082439/P-gp complex. c Polar interaction between BAY-1082439 and P-gp. d Spatial structure of the cavity labeled with residues groups for P-gp to dock with BAY-1082439. e Binding domains and positions of BCRP docking with BAY-1082439. f Structures showing surface of BAY-1082439/BCRP complex. g Polar interaction between BAY-1082439 and BCRP

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