Table 1 The dysregulated circRNAs in various types of cancers
Symbol | Function | Expression | Cancer Type | Mechanism | PMID |
|---|---|---|---|---|---|
circ-ANAPC7 (hsa_circ_0005785) | / | Upregulated | Acute Myeloid Leukemia. | circ-ANAPC7/miR-181 | 29,969,755 |
hsa_circ_0075001 | / | Upregulated | Acute Myeloid Leukemia. | / | 28,971,903 |
circ-DLEU2 | oncogene | Upregulated | Acute Myeloid Leukemia. | circ-DLEU2/miR-496/PRKACB | 30,037,980 |
hsa_circ_0004277 | / | Downregulated | Acute Myeloid Leukemia. | / | 28,282,919 |
circ-HIPK2 | / | Downregulated | Acute Myeloid Leukemia. | circ-HIPK2/miR-124-3p | 29,844,435 |
hsa_circ_0075825 | / | Upregulated | Basal cell carcinoma | / | 27,097,056 |
hsa_circ_0075828 | / | Upregulated | Basal cell carcinoma | / | 27,097,056 |
hsa_circ_0022383 | / | Downregulated | Basal cell carcinoma | / | 27,298,156 |
hsa_circ_0022392 | / | Downregulated | Basal cell carcinoma | / | 27,298,156 |
circRNA-MYLK(hsa_circ_0002768) | oncogene | Upregulated | Bladder Cancer | circRNA-MYLK/miR-29a/VEGFA/VEGFR2 | 28,687,357 |
circTCF25(hsa_circ_0041103) | oncogene | Upregulated | Bladder Cancer | circTCF25/miR-103-3p/miR-107/CDK6 | 27,484,176 |
circ-BCRC4 | tumor suppressor | Downregulated | Bladder Cancer | circ-BCRC4.miR-101/EZH2 | 29,270,748 |
circ-ITCH | tumor suppressor | Downregulated | Bladder Cancer | circ-ITCH/miR-17/miR-224/p21/PTEN | 29,386,015 |
circHIPK3 | tumor suppressor | Downregulated | Bladder Cancer | circHIPK3/miR-558/HPSE | 28,794,202 |
circ-ABCB10 (hsa_circ_0008717) | oncogene | Upregulated | Breast Cancer | circ-ABCB10/miR-1271 | 28,744,405 |
circ-DENND4C | oncogene | Upregulated | Breast Cancer | HIF1α/circ-DENND4C | 28,739,726 |
circGFRA1 (hsa_circ_0005239) | oncogene | Upregulated | Breast Cancer | circGFRA1/miR-34a/GFRA1 | 29,037,220 |
hsa_circ_0001982 | oncogene | Upregulated | Breast Cancer | hsa_circ_0001982/miR-143 | 28,933,584 |
hsa_circ_0011946 | oncogene | Upregulated | Breast Cancer | hsa_circ_0011946/miR-26a/miR-26b / RFC3 | 29,593,432 |
circ-Foxo3 | tumor suppressor | Downregulated | Breast Cancer | p53/miR-22/ miR-136/ miR-138/ miR-149/ miR-433/ miR-762/ miR-3614-5p/ miR-3622b-5p | 27,886,165/26657152 |
hsa_circ_000911 | tumor suppressor | Downregulated | Breast Cancer | hsa_circ_000911/miR-449a/Notch1 | 29,431,182 |
hsa_circ_0000284 | oncogene | Upregulated | Cervical Cancer | hsa_circ_0000284/miR-506/Snail-2 | 29,511,454 |
hsa_circ_0023404 | oncogene | Upregulated | Cervical Cancer | hsa_circ_0023404/miR-5047/VEGFA | 31,082,770 |
CDR1as (hsa_circ_0001946,ciRS-7) | oncogene | Upregulated | Cholangiocarcinoma | / | 29,424,892 |
hsa_circ_0001649 | tumor suppressor | Downregulated | Cholangiocarcinoma | / | 29,337,065 |
circ-CBFB | oncogene | Upregulated | Chronic Lymphocytic Leukemia | circ-CBFB/miR-607/FZD3/Wnt/β-catenin | 29,902,450 |
circ_0132266 | / | Downregulated | Chronic Lymphocytic Leukemia | circ_0132266/miR-337-3p/PML | 31,152,142 |
circ-BA9.3 | oncogene | Upregulated | Chronic Myelogenous Leukaemia | circ-BA9.3/ABL1/BCR-ABL1 | 30,224,298 |
hsa_circ_0080145 | oncogene | Upregulated | Chronic Myelogenous Leukaemia | hsa_circ_0080145/miR-29b | 30,205,959 |
hsa_circ_0001793 | / | Upregulated | Colorectal Cancer | / | 25,624,062 |
circ_001569 | oncogene | Upregulated | Colorectal Cancer | circ_001569/miR-145/E2F5/BAG4/FMNL2 | 27,058,418 |
circ-BANP | oncogene | Upregulated | Colorectal Cancer | circ-BANP/p-Akt | 28,103,507 |
circCCDC66 | oncogene | Upregulated | Colorectal Cancer | circCCDC66/miR-33b/ miR-93 | 28,249,903 |
circHIPK3 | oncogene | Upregulated | Colorectal Cancer | circ-HIPK/miR-7/FAK//IGF1R/ EGFR/YY1 | 29,549,306 |
hsa_circ_0000069 | oncogene | Upregulated | Colorectal Cancer | / | 28,003,761 |
CDR1as (hsa_circ_0001946, ciRS-7) | oncogene | Upregulated | Colorectal Cancer | hsa_circ_0001946/miR-7/EGFR/ RAF1 | 25,624,062/28174233 |
hsa_circ_0007534 | oncogene | Upregulated | Colorectal Cancer | / | 29,364,478 |
hsa_circ_000984 | oncogene | Upregulated | Colorectal Cancer | hsa_circ_000984/miR-106b/CDK6 | 29,207,676 |
hsa_circ_0020397 | oncogene | Upregulated | Colorectal Cancer | hsa_circ_0020397/miR-138/TERT/ PD-L1 | 28,707,774 |
hsa_circ_0136666 | oncogene | Upregulated | Colorectal Cancer | hsa_circ_0136666/miR-136/SH2B1 | 30,370,521 |
hsa_circ_0000523 | / | Downregulated | Colorectal Cancer | / | 25,624,062 |
hsa_circ_0001346 | / | Downregulated | Colorectal Cancer | / | 25,624,062 |
hsa_circ_0001649 | / | Downregulated | Colorectal Cancer | / | 29,421,663 |
cir-ITCH | tumor suppressor | Downregulated | Colorectal Cancer | cir-ITCH/miR-7/ miR-20a/ miR-214/Wnt/β-catenin | 26,110,611 |
hsa_circ_0003906 | tumor suppressor | Downregulated | Colorectal Cancer | / | 29,123,417 |
cric-FBXW7 (hsa_circ_001988) | tumor suppressor | Downregulated | Colorectal Cancer | / | 26,884,878 |
hsa_circ_0070933 | / | Upregulated | Cutaneous squamous cell carcinoma | / | 27,298,156 |
hsa_circ_0070934 | / | Upregulated | Cutaneous squamous cell carcinoma | / | 27,298,156 |
hsa_circ_0022383 | / | Downregulated | Cutaneous squamous cell carcinoma | / | 27,298,156 |
hsa_circ_0022392 | / | Downregulated | Cutaneous squamous cell carcinoma | / | 27,298,156 |
circ-HIPK3 | oncogene | Upregulated | Epithelial Ovarian Cancer | / | 29,949,144 |
circ-SLC7A5 | oncogene | Upregulated | Esophageal squamous cell carcinoma | / | 31,726,270 |
circPRKCI (hsa_circ_0067934) | oncogene | Upregulated | Esophageal squamous cell carcinoma | / | 27,752,108 |
hsa_circ_0000518 | / | Downregulated | Esophageal squamous cell carcinoma | hsa_circ_0000518/miR-181a-2/ miR-512-5p/ miR-521/ miR-556-5p/ miR-663b/ miR-1204 | 27,465,405 |
hsa_circ_0000554 | / | Downregulated | Esophageal squamous cell carcinoma | hsa_circ_0000554/miR-30c-1/ miR-30c-2/ miR-122/ miR-139-3p/ miR-339-5p/ miR-1912 | 27,465,405 |
circ-ITCH | tumor suppressor | Downregulated | Esophageal squamous cell carcinoma | miR-7/ miR-17/ miR-214/Wnt/β-catenin | 25,749,389 |
circPVT1 (hsa_circ_0001821) | / | Upregulated | Gastric Cancer | / | 31,616,472 |
circLMTK2 | oncogene | Upregulated | Gastric Cancer | circLMTK2/miR-150-5p/c-Myc | 31,722,712 |
has-circRNA7690–15 | oncogene | Upregulated | Gastric Cancer | / | 28,980,874 |
hsa_circ_0047905 | oncogene | Upregulated | Gastric Cancer | / | 28,980,874 |
hsa_circ_0138960 | oncogene | Upregulated | Gastric Cancer | / | 28,980,874 |
hsa_circ_0001017 | / | Downregulated | Gastric Cancer | / | 29,098,316 |
hsa_circ_0001649 | / | Downregulated | Gastric Cancer | / | 28,167,847 |
hsa_circ_0003159 | / | Downregulated | Gastric Cancer | / | 28,618,205 |
hsa_circ_0014717 | / | Downregulated | Gastric Cancer | / | 28,544,609 |
hsa_circ_0061276 | / | Downregulated | Gastric Cancer | / | 29,098,316 |
hsa_circ_0074362 | / | Downregulated | Gastric Cancer | / | 29,240,459 |
hsa_circ_002059 | tumor suppressor | Downregulated | Gastric Cancer | / | 25,689,795 |
circ-LPHN2 (hsa_ circRNA_100269) | tumor suppressor | Downregulated | Gastric Cancer | hsa_ circRNA_100269/miR-630 | 28,657,541 |
circ-HuR (hsa_circ_0049027) | tumor suppressor | Downregulated | Gastric Cancer | circ-HuR/CNBP | 31,718,709 |
circLARP4 | tumor suppressor | Downregulated | Gastric Cancer | circLARP4/miR-424/LATS1 | 28,893,265 |
hsa_circ_0000096 | tumor suppressor | Downregulated | Gastric Cancer | hsa_circ_0000096/cyclin D1/CDK6/ MMP2/ MMP9 | 28,081,541 |
hsa_circ_0000181 | tumor suppressor | Downregulated | Gastric Cancer | / | 28,940,688 |
hsa_circ_0000190 | tumor suppressor | Downregulated | Gastric Cancer | / | 28,130,019 |
hsa_circ_0000520 | tumor suppressor | Downregulated | Gastric Cancer | / | 29,103,021 |
hsa_circ_0000745 | tumor suppressor | Downregulated | Gastric Cancer | / | 28,974,900 |
hsa_circ_0001895 | tumor suppressor | Downregulated | Gastric Cancer | / | 28,443,463 |
hsa_circ_0067582 | tumor suppressor | Downregulated | Gastric Cancer | / | 31,721,300 |
circ-VCAN | / | Upregulated | Gliomas | / | 26,873,924 |
circ_0001730 | oncogene | Upregulated | Gliomas | circ_0001730/miR-326/Wnt7B | 31,304,776 |
circ-SHKBP1 | oncogene | Upregulated | Gliomas | circ-SHKBP1/miR-544a/miR-379/FOXP1/FOXP2 | 29,499,945 |
circ-ZNF292 | oncogene | Upregulated | Gliomas | circ-ZNF292/Wnt/β-catenin | 27,613,831 |
circTTBK2 (hsa_circ_0000594) | oncogene | Upregulated | Gliomas | circTTBK2/miR-217/HNF1β/Derlin-1 | 28,219,405 |
cric-FBXW7 (hsa_circ_001988) | oncogene | Upregulated | Gliomas | / | 28,903,484 |
hsa_circ_0046701 | oncogene | Upregulated | Gliomas | hsa_circ_0046701/miR-142/ITGB8 | 29,337,055 |
CDR1as (hsa_circ_0001946,ciRS-7) | / | Downregulated | Gliomas | miR-671-5p/CDR1as/CDR1/VSNL1 | 26,683,098 |
circ-BRAF | / | Downregulated | Gliomas | / | 28,236,760 |
circ-SHPRH | tumor suppressor | Downregulated | Gliomas | / | 29,343,848 |
circSMARCA5(hsa_circ_0001445) | tumor suppressor | Downregulated | Gliomas | circSMARCA5/SRSF1 | 29,415,469 |
circRNA_100338 | / | Upregulated | Hepatocellular Carcinoma | circRNA_100338/miR-141-3p | 31,157,168/28710406 |
hsa_circ_0000284 | / | Upregulated | Hepatocellular Carcinoma | hsa_circ_0000284/miR-124/miR-152 /miR-193a/miR-29a/miR-29b/miR-338/miR-379/miR-584/miR-654 | 27,050,392 |
circ_000839 | oncogene | Upregulated | Hepatocellular Carcinoma | circ_000839/miR-200b | 28,695,771 |
circPRKCI (hsa_circ_0067934) | oncogene | Upregulated | Hepatocellular Carcinoma | has_circ_0067934/miR-1324/FZD5/Wnt/β-catenin | 29,458,020 |
hsa_circ_0005075 | oncogene | Upregulated | Hepatocellular Carcinoma | / | 27,258,521 |
CDR1as (hsa_circ_0001946, ciRS-7) | / | Downregulated | Hepatocellular Carcinoma | hsa_circ_0001946/miR-7/EGFR/CCNE1/PIK3CD | 28,892,615/27391479 |
hsa_circ_0001649 | / | Downregulated | Hepatocellular Carcinoma | / | 26,600,397 |
hsa_circ_0004018 | / | Downregulated | Hepatocellular Carcinoma | / | 28,938,566 |
hsa_circ_0067531 | / | Downregulated | Hepatocellular Carcinoma | / | 29,251,325 |
circC3P1 | tumor suppressor | Downregulated | Hepatocellular Carcinoma | circC3P1/miR-4641/PCK1 | 29,608,893 |
circMTO1 (hsa_circ_0007874) | tumor suppressor | Downregulated | Hepatocellular Carcinoma | circMTO1/miR-9/p21 | 28,520,103 |
circSMARCA5 (hsa_circ_0001445) | tumor suppressor | Downregulated | Hepatocellular Carcinoma | circSMARCA5 /miR-17-3p/miR-181-5p/TIMP3 | 29,378,234 |
circZKSCAN1 (hsa_circ_0001727) | tumor suppressor | Downregulated | Hepatocellular Carcinoma | / | 28,211,215 |
hsa_circ_0003570 | tumor suppressor | Downregulated | Hepatocellular Carcinoma | / | 28,493,512 |
hsa_circ_0005986 | tumor suppressor | Downregulated | Hepatocellular Carcinoma | hsa_circ_0005986/miR-129/Notch1 | 28,410,211 |
circRNA_100876 | / | Upregulated | Lung Cancer | / | 28,343,871 |
circ-CER | oncogene | Upregulated | Lung Cancer | circ-CER/miR-136/MMP13 | 28,343,871 |
circMAN2B2 | oncogene | Upregulated | Lung Cancer | circMAN2B2/miR-1275/FOXK1 | 29,550,475 |
circPRKCI (hsa_circ_0067934) | oncogene | Upregulated | Lung Cancer | circPRKCI/miR-545/ miR-589/E2F7 | 29,588,350 |
circRNA_102231 | oncogene | Upregulated | Lung Cancer | / | 29,602,132 |
hsa_circ_0000064 | oncogene | Upregulated | Lung Cancer | hsa_circ_0000064/MMP2/MMP9 | 29,223,555 |
hsa_circ_0007385 | oncogene | Upregulated | Lung Cancer | hsa_circ_0007385/miR-181 | 29,372,377 |
hsa_circ_0012673 | oncogene | Upregulated | Lung Cancer | hsa_circ_0012673/miR-22/ErbB3 | 29,366,790 |
hsa_circ_0013958 | oncogene | Upregulated | Lung Cancer | hsa_circ_0013958/miR-134/cyclin D1 | 28,685,964 |
hsa_circ_0014130 | oncogene | Upregulated | Lung Cancer | / | 29,440,731 |
circRNA-FOXO3 | tumor suppressor | Downregulated | Lung Cancer | / | 29,620,202 |
hsa_circ_0013958 | tumor suppressor | Downregulated | Lung Cancer | hsa_circ_0013958/miR-7/miR-214/Wnt/b-catenin | 27,642,589 |
circDOCK1 | oncogene | Upregulated | Oral Squamous Cell Carcinoma | circDOCK1/mi-196a/BIRC3 | 29,286,141 |
hsa_circRNA_103801 | / | Upregulated | Osteosarcoma | hsa_circRNA_103801/miR-370 | 28,957,794 |
circ_0102049 | oncogene | Upregulated | Osteosarcoma | circ_0102049/miR-1304-5p/MDM2 | 31,727,503 |
circ-UBAP2 | oncogene | Upregulated | Osteosarcoma | circ-UBAP2 /miR-143 | 28,977,896 |
circPVT1 (hsa_circ_0001821) | oncogene | Upregulated | Osteosarcoma | circPVT1/ABCB1 | 29,559,849 |
hsa_circ_0001564 | oncogene | Upregulated | Osteosarcoma | hsa_circ_0001564/miR-29c | 29,229,385 |
hsa_circ_0009910 | oncogene | Upregulated | Osteosarcoma | circ-UBAP2/miR-449a/IL-6R/JAK1/STAT3 | 29,117,539 |
hsa_circ_0016347 | oncogene | Upregulated | Osteosarcoma | hsa_circ_0016347/miR-124/caspase-1 | 28,424,426 |
hsa_circRNA_104980 | / | Downregulated | Osteosarcoma | / | 28,957,794 |
hsa_circ_0005397 | / | Upregulated | Pancreatic cancer | hsa_circ_0005397/miR-26b/miR-125a/miR-181a/miR-330/miR-382 | 27,997,903 |
circ-ASH2L | oncogene | Upregulated | Pancreatic cancer | circ-ASH2L/miR-34a/Notch1 | 31,718,694 |
circ-LDLRAD3 | oncogene | Upregulated | Pancreatic cancer | / | 29,307,994 |
circRNA_100782 | oncogene | Upregulated | Pancreatic cancer | circRNA_100782/miR-124/IL6/STAT | 29,255,366 |
circ-ANAPC7 (hsa_circ_0005785) | / | Downregulated | Pancreatic cancer | hsa_circ_0005785/miR-181a/miR-181b/miR-181d/miR-338/miR-526b | 27,997,903 |
circ-SMARCA5 | oncogene | Upregulated | Prostate cancer | / | 28,765,045 |
circMTO1 (hsa_circ_0007874) | tumor suppressor | Downregulated | Prostate cancer | circMTO1/miR-17-5p | 31,713,278 |