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Table 1 The dysregulated circRNAs in various types of cancers

From: Circular RNAs in the tumour microenvironment

Symbol Function Expression Cancer Type Mechanism PMID
circ-ANAPC7 (hsa_circ_0005785) / Upregulated Acute Myeloid Leukemia. circ-ANAPC7/miR-181 29,969,755
hsa_circ_0075001 / Upregulated Acute Myeloid Leukemia. / 28,971,903
circ-DLEU2 oncogene Upregulated Acute Myeloid Leukemia. circ-DLEU2/miR-496/PRKACB 30,037,980
hsa_circ_0004277 / Downregulated Acute Myeloid Leukemia. / 28,282,919
circ-HIPK2 / Downregulated Acute Myeloid Leukemia. circ-HIPK2/miR-124-3p 29,844,435
hsa_circ_0075825 / Upregulated Basal cell carcinoma / 27,097,056
hsa_circ_0075828 / Upregulated Basal cell carcinoma / 27,097,056
hsa_circ_0022383 / Downregulated Basal cell carcinoma / 27,298,156
hsa_circ_0022392 / Downregulated Basal cell carcinoma / 27,298,156
circRNA-MYLK(hsa_circ_0002768) oncogene Upregulated Bladder Cancer circRNA-MYLK/miR-29a/VEGFA/VEGFR2 28,687,357
circTCF25(hsa_circ_0041103) oncogene Upregulated Bladder Cancer circTCF25/miR-103-3p/miR-107/CDK6 27,484,176
circ-BCRC4 tumor suppressor Downregulated Bladder Cancer circ-BCRC4.miR-101/EZH2 29,270,748
circ-ITCH tumor suppressor Downregulated Bladder Cancer circ-ITCH/miR-17/miR-224/p21/PTEN 29,386,015
circHIPK3 tumor suppressor Downregulated Bladder Cancer circHIPK3/miR-558/HPSE 28,794,202
circ-ABCB10 (hsa_circ_0008717) oncogene Upregulated Breast Cancer circ-ABCB10/miR-1271 28,744,405
circ-DENND4C oncogene Upregulated Breast Cancer HIF1α/circ-DENND4C 28,739,726
circGFRA1 (hsa_circ_0005239) oncogene Upregulated Breast Cancer circGFRA1/miR-34a/GFRA1 29,037,220
hsa_circ_0001982 oncogene Upregulated Breast Cancer hsa_circ_0001982/miR-143 28,933,584
hsa_circ_0011946 oncogene Upregulated Breast Cancer hsa_circ_0011946/miR-26a/miR-26b / RFC3 29,593,432
circ-Foxo3 tumor suppressor Downregulated Breast Cancer p53/miR-22/ miR-136/ miR-138/ miR-149/ miR-433/ miR-762/ miR-3614-5p/ miR-3622b-5p 27,886,165/26657152
hsa_circ_000911 tumor suppressor Downregulated Breast Cancer hsa_circ_000911/miR-449a/Notch1 29,431,182
hsa_circ_0000284 oncogene Upregulated Cervical Cancer hsa_circ_0000284/miR-506/Snail-2 29,511,454
hsa_circ_0023404 oncogene Upregulated Cervical Cancer hsa_circ_0023404/miR-5047/VEGFA 31,082,770
CDR1as (hsa_circ_0001946,ciRS-7) oncogene Upregulated Cholangiocarcinoma / 29,424,892
hsa_circ_0001649 tumor suppressor Downregulated Cholangiocarcinoma / 29,337,065
circ-CBFB oncogene Upregulated Chronic Lymphocytic Leukemia circ-CBFB/miR-607/FZD3/Wnt/β-catenin 29,902,450
circ_0132266 / Downregulated Chronic Lymphocytic Leukemia circ_0132266/miR-337-3p/PML 31,152,142
circ-BA9.3 oncogene Upregulated Chronic Myelogenous Leukaemia circ-BA9.3/ABL1/BCR-ABL1 30,224,298
hsa_circ_0080145 oncogene Upregulated Chronic Myelogenous Leukaemia hsa_circ_0080145/miR-29b 30,205,959
hsa_circ_0001793 / Upregulated Colorectal Cancer / 25,624,062
circ_001569 oncogene Upregulated Colorectal Cancer circ_001569/miR-145/E2F5/BAG4/FMNL2 27,058,418
circ-BANP oncogene Upregulated Colorectal Cancer circ-BANP/p-Akt 28,103,507
circCCDC66 oncogene Upregulated Colorectal Cancer circCCDC66/miR-33b/ miR-93 28,249,903
circHIPK3 oncogene Upregulated Colorectal Cancer circ-HIPK/miR-7/FAK//IGF1R/ EGFR/YY1 29,549,306
hsa_circ_0000069 oncogene Upregulated Colorectal Cancer / 28,003,761
CDR1as (hsa_circ_0001946, ciRS-7) oncogene Upregulated Colorectal Cancer hsa_circ_0001946/miR-7/EGFR/ RAF1 25,624,062/28174233
hsa_circ_0007534 oncogene Upregulated Colorectal Cancer / 29,364,478
hsa_circ_000984 oncogene Upregulated Colorectal Cancer hsa_circ_000984/miR-106b/CDK6 29,207,676
hsa_circ_0020397 oncogene Upregulated Colorectal Cancer hsa_circ_0020397/miR-138/TERT/ PD-L1 28,707,774
hsa_circ_0136666 oncogene Upregulated Colorectal Cancer hsa_circ_0136666/miR-136/SH2B1 30,370,521
hsa_circ_0000523 / Downregulated Colorectal Cancer / 25,624,062
hsa_circ_0001346 / Downregulated Colorectal Cancer / 25,624,062
hsa_circ_0001649 / Downregulated Colorectal Cancer / 29,421,663
cir-ITCH tumor suppressor Downregulated Colorectal Cancer cir-ITCH/miR-7/ miR-20a/ miR-214/Wnt/β-catenin 26,110,611
hsa_circ_0003906 tumor suppressor Downregulated Colorectal Cancer / 29,123,417
cric-FBXW7 (hsa_circ_001988) tumor suppressor Downregulated Colorectal Cancer / 26,884,878
hsa_circ_0070933 / Upregulated Cutaneous squamous cell carcinoma / 27,298,156
hsa_circ_0070934 / Upregulated Cutaneous squamous cell carcinoma / 27,298,156
hsa_circ_0022383 / Downregulated Cutaneous squamous cell carcinoma / 27,298,156
hsa_circ_0022392 / Downregulated Cutaneous squamous cell carcinoma / 27,298,156
circ-HIPK3 oncogene Upregulated Epithelial Ovarian Cancer / 29,949,144
circ-SLC7A5 oncogene Upregulated Esophageal squamous cell carcinoma / 31,726,270
circPRKCI (hsa_circ_0067934) oncogene Upregulated Esophageal squamous cell carcinoma / 27,752,108
hsa_circ_0000518 / Downregulated Esophageal squamous cell carcinoma hsa_circ_0000518/miR-181a-2/ miR-512-5p/ miR-521/ miR-556-5p/ miR-663b/ miR-1204 27,465,405
hsa_circ_0000554 / Downregulated Esophageal squamous cell carcinoma hsa_circ_0000554/miR-30c-1/ miR-30c-2/ miR-122/ miR-139-3p/ miR-339-5p/ miR-1912 27,465,405
circ-ITCH tumor suppressor Downregulated Esophageal squamous cell carcinoma miR-7/ miR-17/ miR-214/Wnt/β-catenin 25,749,389
circPVT1 (hsa_circ_0001821) / Upregulated Gastric Cancer / 31,616,472
circLMTK2 oncogene Upregulated Gastric Cancer circLMTK2/miR-150-5p/c-Myc 31,722,712
has-circRNA7690–15 oncogene Upregulated Gastric Cancer / 28,980,874
hsa_circ_0047905 oncogene Upregulated Gastric Cancer / 28,980,874
hsa_circ_0138960 oncogene Upregulated Gastric Cancer / 28,980,874
hsa_circ_0001017 / Downregulated Gastric Cancer / 29,098,316
hsa_circ_0001649 / Downregulated Gastric Cancer / 28,167,847
hsa_circ_0003159 / Downregulated Gastric Cancer / 28,618,205
hsa_circ_0014717 / Downregulated Gastric Cancer / 28,544,609
hsa_circ_0061276 / Downregulated Gastric Cancer / 29,098,316
hsa_circ_0074362 / Downregulated Gastric Cancer / 29,240,459
hsa_circ_002059 tumor suppressor Downregulated Gastric Cancer / 25,689,795
circ-LPHN2 (hsa_ circRNA_100269) tumor suppressor Downregulated Gastric Cancer hsa_ circRNA_100269/miR-630 28,657,541
circ-HuR (hsa_circ_0049027) tumor suppressor Downregulated Gastric Cancer circ-HuR/CNBP 31,718,709
circLARP4 tumor suppressor Downregulated Gastric Cancer circLARP4/miR-424/LATS1 28,893,265
hsa_circ_0000096 tumor suppressor Downregulated Gastric Cancer hsa_circ_0000096/cyclin D1/CDK6/ MMP2/ MMP9 28,081,541
hsa_circ_0000181 tumor suppressor Downregulated Gastric Cancer / 28,940,688
hsa_circ_0000190 tumor suppressor Downregulated Gastric Cancer / 28,130,019
hsa_circ_0000520 tumor suppressor Downregulated Gastric Cancer / 29,103,021
hsa_circ_0000745 tumor suppressor Downregulated Gastric Cancer / 28,974,900
hsa_circ_0001895 tumor suppressor Downregulated Gastric Cancer / 28,443,463
hsa_circ_0067582 tumor suppressor Downregulated Gastric Cancer / 31,721,300
circ-VCAN / Upregulated Gliomas / 26,873,924
circ_0001730 oncogene Upregulated Gliomas circ_0001730/miR-326/Wnt7B 31,304,776
circ-SHKBP1 oncogene Upregulated Gliomas circ-SHKBP1/miR-544a/miR-379/FOXP1/FOXP2 29,499,945
circ-ZNF292 oncogene Upregulated Gliomas circ-ZNF292/Wnt/β-catenin 27,613,831
circTTBK2 (hsa_circ_0000594) oncogene Upregulated Gliomas circTTBK2/miR-217/HNF1β/Derlin-1 28,219,405
cric-FBXW7 (hsa_circ_001988) oncogene Upregulated Gliomas / 28,903,484
hsa_circ_0046701 oncogene Upregulated Gliomas hsa_circ_0046701/miR-142/ITGB8 29,337,055
CDR1as (hsa_circ_0001946,ciRS-7) / Downregulated Gliomas miR-671-5p/CDR1as/CDR1/VSNL1 26,683,098
circ-BRAF / Downregulated Gliomas / 28,236,760
circ-SHPRH tumor suppressor Downregulated Gliomas / 29,343,848
circSMARCA5(hsa_circ_0001445) tumor suppressor Downregulated Gliomas circSMARCA5/SRSF1 29,415,469
circRNA_100338 / Upregulated Hepatocellular Carcinoma circRNA_100338/miR-141-3p 31,157,168/28710406
hsa_circ_0000284 / Upregulated Hepatocellular Carcinoma hsa_circ_0000284/miR-124/miR-152 /miR-193a/miR-29a/miR-29b/miR-338/miR-379/miR-584/miR-654 27,050,392
circ_000839 oncogene Upregulated Hepatocellular Carcinoma circ_000839/miR-200b 28,695,771
circPRKCI (hsa_circ_0067934) oncogene Upregulated Hepatocellular Carcinoma has_circ_0067934/miR-1324/FZD5/Wnt/β-catenin 29,458,020
hsa_circ_0005075 oncogene Upregulated Hepatocellular Carcinoma / 27,258,521
CDR1as (hsa_circ_0001946, ciRS-7) / Downregulated Hepatocellular Carcinoma hsa_circ_0001946/miR-7/EGFR/CCNE1/PIK3CD 28,892,615/27391479
hsa_circ_0001649 / Downregulated Hepatocellular Carcinoma / 26,600,397
hsa_circ_0004018 / Downregulated Hepatocellular Carcinoma / 28,938,566
hsa_circ_0067531 / Downregulated Hepatocellular Carcinoma / 29,251,325
circC3P1 tumor suppressor Downregulated Hepatocellular Carcinoma circC3P1/miR-4641/PCK1 29,608,893
circMTO1 (hsa_circ_0007874) tumor suppressor Downregulated Hepatocellular Carcinoma circMTO1/miR-9/p21 28,520,103
circSMARCA5 (hsa_circ_0001445) tumor suppressor Downregulated Hepatocellular Carcinoma circSMARCA5 /miR-17-3p/miR-181-5p/TIMP3 29,378,234
circZKSCAN1 (hsa_circ_0001727) tumor suppressor Downregulated Hepatocellular Carcinoma / 28,211,215
hsa_circ_0003570 tumor suppressor Downregulated Hepatocellular Carcinoma / 28,493,512
hsa_circ_0005986 tumor suppressor Downregulated Hepatocellular Carcinoma hsa_circ_0005986/miR-129/Notch1 28,410,211
circRNA_100876 / Upregulated Lung Cancer / 28,343,871
circ-CER oncogene Upregulated Lung Cancer circ-CER/miR-136/MMP13 28,343,871
circMAN2B2 oncogene Upregulated Lung Cancer circMAN2B2/miR-1275/FOXK1 29,550,475
circPRKCI (hsa_circ_0067934) oncogene Upregulated Lung Cancer circPRKCI/miR-545/ miR-589/E2F7 29,588,350
circRNA_102231 oncogene Upregulated Lung Cancer / 29,602,132
hsa_circ_0000064 oncogene Upregulated Lung Cancer hsa_circ_0000064/MMP2/MMP9 29,223,555
hsa_circ_0007385 oncogene Upregulated Lung Cancer hsa_circ_0007385/miR-181 29,372,377
hsa_circ_0012673 oncogene Upregulated Lung Cancer hsa_circ_0012673/miR-22/ErbB3 29,366,790
hsa_circ_0013958 oncogene Upregulated Lung Cancer hsa_circ_0013958/miR-134/cyclin D1 28,685,964
hsa_circ_0014130 oncogene Upregulated Lung Cancer / 29,440,731
circRNA-FOXO3 tumor suppressor Downregulated Lung Cancer / 29,620,202
hsa_circ_0013958 tumor suppressor Downregulated Lung Cancer hsa_circ_0013958/miR-7/miR-214/Wnt/b-catenin 27,642,589
circDOCK1 oncogene Upregulated Oral Squamous Cell Carcinoma circDOCK1/mi-196a/BIRC3 29,286,141
hsa_circRNA_103801 / Upregulated Osteosarcoma hsa_circRNA_103801/miR-370 28,957,794
circ_0102049 oncogene Upregulated Osteosarcoma circ_0102049/miR-1304-5p/MDM2 31,727,503
circ-UBAP2 oncogene Upregulated Osteosarcoma circ-UBAP2 /miR-143 28,977,896
circPVT1 (hsa_circ_0001821) oncogene Upregulated Osteosarcoma circPVT1/ABCB1 29,559,849
hsa_circ_0001564 oncogene Upregulated Osteosarcoma hsa_circ_0001564/miR-29c 29,229,385
hsa_circ_0009910 oncogene Upregulated Osteosarcoma circ-UBAP2/miR-449a/IL-6R/JAK1/STAT3 29,117,539
hsa_circ_0016347 oncogene Upregulated Osteosarcoma hsa_circ_0016347/miR-124/caspase-1 28,424,426
hsa_circRNA_104980 / Downregulated Osteosarcoma / 28,957,794
hsa_circ_0005397 / Upregulated Pancreatic cancer hsa_circ_0005397/miR-26b/miR-125a/miR-181a/miR-330/miR-382 27,997,903
circ-ASH2L oncogene Upregulated Pancreatic cancer circ-ASH2L/miR-34a/Notch1 31,718,694
circ-LDLRAD3 oncogene Upregulated Pancreatic cancer / 29,307,994
circRNA_100782 oncogene Upregulated Pancreatic cancer circRNA_100782/miR-124/IL6/STAT 29,255,366
circ-ANAPC7 (hsa_circ_0005785) / Downregulated Pancreatic cancer hsa_circ_0005785/miR-181a/miR-181b/miR-181d/miR-338/miR-526b 27,997,903
circ-SMARCA5 oncogene Upregulated Prostate cancer / 28,765,045
circMTO1 (hsa_circ_0007874) tumor suppressor Downregulated Prostate cancer circMTO1/miR-17-5p 31,713,278