|
circRNAs and CAEs
|
circ-MYLK
|
Upregulated
|
oncogene
|
Breast cancer
|
Proliferation, migration, apoptosis, angiogenesis, metastasis, EMT
|
TNM stage, pathological grade
|
circ-MYLK/miR-29a/VEGFA/VEGFR2
|
|
circ-SMARCA5
|
Downregulated
|
tumor suppressor
|
Glioblastoma multiform
|
Angiogenesis
|
Overall Survival, Progression-Free Survival
|
circ-SMARCA5/SRSF1/VEGFA
|
|
circ-DICER1
|
Upregulated
|
oncogene
|
Glioma
|
Proliferation, migration, angiogenesis
|
/
|
MOV10/circ-DICER1/ miR-103a-3p/miR-382-5p/ZIC4
|
|
circ-SHKBP1
|
Upregulated
|
oncogene
|
Glioma
|
Proliferation, migration, angiogenesis
|
/
|
circ-SHKBP1/miR-544a/FOXP1, circ-SHKBP1/miR-379/FOXP2
|
|
circ-IARS
|
Upregulated
|
oncogene
|
Pancreatic ductal adenocarcinoma
|
Invasion, metastasis, endothelial monolayer permeability
|
Vascular invasion, TNM stage, liver metastasis, postoperative survival time
|
circ-IARS/miR-122/RhoA/F-actin/ZO-1
|
|
circ-HIPK3
|
Downregulated
|
tumor suppressor
|
Bladder cancer
|
Proliferation, migration, invasion, angiogenesis, metastasis
|
Pathological grade, tumor invasion, lymph node metastasis
|
circ-HIPK3/miR-558/HPSE
|
|
ciRS-7
|
Upregulated
|
oncogene
|
Multiple tumours
|
Angiogenesis, immune and stromal infiltration, ECM organization, integrin and collagen binding
|
/
|
cir-DR1as/TGF-β signaling pathway/ECM–receptor interaction
|
|
circRNAs and immune cells
|
ciRS-7
|
Upregulated
|
oncogened
|
Esophageal squamous cell carcinoma
|
Proliferation, migration, invasion, metastasis
|
TNM stage, pathological grade, overall survival, disease-free survival
|
ciRS-7miR-7/KLF4/NF-κB
|
|
Multiple tumours
|
Angiogenesis, immune and stromal infiltration, ECM organization, integrin and collagen binding
|
/
|
cir-DR1as/TGF-β signaling pathway/ECM– receptor interaction
|
|
has_circ_0020397
|
Upregulated
|
oncogene
|
Colorectal cancer
|
Proliferation, invasion, apoptosis
|
/
|
has_circ_0020397/miR-138/TERT/PD-L1
|
|
hsa_circ_0064428
|
Downregulated
|
tumor suppressor
|
Hepatocellular carcinoma
|
/
|
Tumour size, metastasis, overall survival
|
/
|
|
circRNA-000911
|
Downregulated
|
tumor suppressor
|
Breast cancer
|
Proliferation, migration and invasion, apoptosis
|
/
|
circ-000911/ miR-449a /Notch1/NF-κB
|
|
circ-0000977
|
Upregulated
|
oncogene
|
Pancreatic cancer
|
Immune escape, induction by hypoxia
|
/
|
circ-0000977/miR-153/HIF1α/ADAM1
|
|
circ-Foxo3
|
Downregulated
|
tumor suppressor
|
Breast cancer
|
Proliferation, apoptosis, tumor growth
|
/
|
circ-Foxo3/MDM2/P53/Foxo3
|
|
CircRNAs and CAFs
|
ciRS-7
|
Upregulated
|
oncogene
|
Multiple tumours
|
Angiogenesis, immune and stromal infiltration, ECM organization, integrin and collagen binding
|
/
|
cir-DR1as/TGF-β signaling pathway/ECM– receptor interaction
|
|
circRNAs and CSCs
|
hg19_circ_0005033
|
Upregulated
|
oncogene
|
Laryngeal squamous cell carcinoma
|
Proliferation, migration, invasion, chemotherapy resistance
|
/
|
hg19_circ_0005033/miR-4521/miR-339-5p/STA T5A
|
|
circRNAs and hypoxia
|
circ-DENND2A
|
Upregulated
|
oncogene
|
Glioma
|
Migration, invasion, induction by hypoxia
|
/
|
circ-DENND2A/miR-625-5p/HIF1α
|
|
circ-PIP5K1A
|
Upregulated
|
oncogene
|
Non-small cell lung cancer
|
Proliferation, invasion, migration, metastasis, EMT
|
/
|
circ-PIP5K1A/miR-600/HIF-1α
|
|
circ-0000977
|
Upregulated
|
oncogene
|
Pancreatic cancer
|
Immune escape, induction by hypoxia
|
/
|
circ-0000977/miR-153/HIF1α/ADAM1
|
|
circ-CDR1as
|
Downregulated
|
tumor suppressor
|
Ovarian cancer
|
Proliferation, migration, invasion
|
/
|
circ-CDR1as/miR-135b-5p/HIF1AN
|
|
circ-DENND4C
|
Upregulated
|
oncogene
|
Breast cancer
|
Proliferation, induction by hypoxia
|
/
|
HIF1α/circ-DENN4C
|
|
circRNAs and ECM
|
hsa_circ_0000096
|
Downregulated
|
tumor suppressor
|
Gastric cacner
|
Proliferation, migration
|
Gender, invasion, TNM stage
|
hsa_circ_0000096/MMP2/MMP9
|
|
hsa_circ_0000064
|
Upregulated
|
oncogene
|
Non-small cell lung cancer
|
Proliferation, cell cycle, apoptosis, migration, invasion
|
T stage, TNM stage, lymph node metastasis
|
hsa_circ_0000064/MMP2/MMP9
|
|
ciRS-7
|
Upregulated
|
oncogene
|
Multiple tumours
|
Angiogenesis, immune and stromal infiltration, ECM organization, integrin and collagen binding
|
/
|
cir-DR1as/TGF-β signaling pathway/ECM– receptor interaction
|
|
circ-ERBB2
|
Upregulated
|
oncogene
|
Gastric cacner
|
Proliferation, apoptosis, migration, invasion
|
Tumor size, invasion depth, overall survival
|
circ-ERBB2/miR-637/MMP-19
|
|
hsa_circ_0044520
|
Upregulated
|
/
|
Laryngeal Squamous Cell Carcinoma
|
Collagen synthesis
|
/
|
hsa_circ_0044520/COL1A1
|
|
hsa_circ_0044529
|
Upregulated
|
/
|
Laryngeal Squamous Cell Carcinoma
|
Collagen synthesis
|
/
|
hsa_circ_0044529/COL1A1
|
