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Table 2 The emerging role and mechanistic axis of circRNAs associated with the TME

From: Circular RNAs in the tumour microenvironment

Interaction with TME CircRNA name Expression Function Cancer types Biological activities Clinical correlation Molecular axis
circRNAs and CAEs circ-MYLK Upregulated oncogene Breast cancer Proliferation, migration, apoptosis, angiogenesis, metastasis, EMT TNM stage, pathological grade circ-MYLK/miR-29a/VEGFA/VEGFR2
circ-SMARCA5 Downregulated tumor suppressor Glioblastoma multiform Angiogenesis Overall Survival, Progression-Free Survival circ-SMARCA5/SRSF1/VEGFA
circ-DICER1 Upregulated oncogene Glioma Proliferation, migration, angiogenesis / MOV10/circ-DICER1/ miR-103a-3p/miR-382-5p/ZIC4
circ-SHKBP1 Upregulated oncogene Glioma Proliferation, migration, angiogenesis / circ-SHKBP1/miR-544a/FOXP1, circ-SHKBP1/miR-379/FOXP2
circ-IARS Upregulated oncogene Pancreatic ductal adenocarcinoma Invasion, metastasis, endothelial monolayer permeability Vascular invasion, TNM stage, liver metastasis, postoperative survival time circ-IARS/miR-122/RhoA/F-actin/ZO-1
circ-HIPK3 Downregulated tumor suppressor Bladder cancer Proliferation, migration, invasion, angiogenesis, metastasis Pathological grade, tumor invasion, lymph node metastasis circ-HIPK3/miR-558/HPSE
ciRS-7 Upregulated oncogene Multiple tumours Angiogenesis, immune and stromal infiltration, ECM organization, integrin and collagen binding / cir-DR1as/TGF-β signaling pathway/ECM–receptor interaction
circRNAs and immune cells ciRS-7 Upregulated oncogened Esophageal squamous cell carcinoma Proliferation, migration, invasion, metastasis TNM stage, pathological grade, overall survival, disease-free survival ciRS-7miR-7/KLF4/NF-κB
Multiple tumours Angiogenesis, immune and stromal infiltration, ECM organization, integrin and collagen binding / cir-DR1as/TGF-β signaling pathway/ECM– receptor interaction
has_circ_0020397 Upregulated oncogene Colorectal cancer Proliferation, invasion, apoptosis / has_circ_0020397/miR-138/TERT/PD-L1
hsa_circ_0064428 Downregulated tumor suppressor Hepatocellular carcinoma / Tumour size, metastasis, overall survival /
circRNA-000911 Downregulated tumor suppressor Breast cancer Proliferation, migration and invasion, apoptosis / circ-000911/ miR-449a /Notch1/NF-κB
circ-0000977 Upregulated oncogene Pancreatic cancer Immune escape, induction by hypoxia / circ-0000977/miR-153/HIF1α/ADAM1
circ-Foxo3 Downregulated tumor suppressor Breast cancer Proliferation, apoptosis, tumor growth / circ-Foxo3/MDM2/P53/Foxo3
CircRNAs and CAFs ciRS-7 Upregulated oncogene Multiple tumours Angiogenesis, immune and stromal infiltration, ECM organization, integrin and collagen binding / cir-DR1as/TGF-β signaling pathway/ECM– receptor interaction
circRNAs and CSCs hg19_circ_0005033 Upregulated oncogene Laryngeal squamous cell carcinoma Proliferation, migration, invasion, chemotherapy resistance / hg19_circ_0005033/miR-4521/miR-339-5p/STA T5A
circRNAs and hypoxia circ-DENND2A Upregulated oncogene Glioma Migration, invasion, induction by hypoxia / circ-DENND2A/miR-625-5p/HIF1α
circ-PIP5K1A Upregulated oncogene Non-small cell lung cancer Proliferation, invasion, migration, metastasis, EMT / circ-PIP5K1A/miR-600/HIF-1α
circ-0000977 Upregulated oncogene Pancreatic cancer Immune escape, induction by hypoxia / circ-0000977/miR-153/HIF1α/ADAM1
circ-CDR1as Downregulated tumor suppressor Ovarian cancer Proliferation, migration, invasion / circ-CDR1as/miR-135b-5p/HIF1AN
circ-DENND4C Upregulated oncogene Breast cancer Proliferation, induction by hypoxia / HIF1α/circ-DENN4C
circRNAs and ECM hsa_circ_0000096 Downregulated tumor suppressor Gastric cacner Proliferation, migration Gender, invasion, TNM stage hsa_circ_0000096/MMP2/MMP9
hsa_circ_0000064 Upregulated oncogene Non-small cell lung cancer Proliferation, cell cycle, apoptosis, migration, invasion T stage, TNM stage, lymph node metastasis hsa_circ_0000064/MMP2/MMP9
ciRS-7 Upregulated oncogene Multiple tumours Angiogenesis, immune and stromal infiltration, ECM organization, integrin and collagen binding / cir-DR1as/TGF-β signaling pathway/ECM– receptor interaction
circ-ERBB2 Upregulated oncogene Gastric cacner Proliferation, apoptosis, migration, invasion Tumor size, invasion depth, overall survival circ-ERBB2/miR-637/MMP-19
hsa_circ_0044520 Upregulated / Laryngeal Squamous Cell Carcinoma Collagen synthesis / hsa_circ_0044520/COL1A1
hsa_circ_0044529 Upregulated / Laryngeal Squamous Cell Carcinoma Collagen synthesis / hsa_circ_0044529/COL1A1