Table 3 The emerging role and mechanistic axis of circRNAs associated with drug resistance in various tumours
CircRNA name | Expression | Function | Cancer types | Biological activities | Clinical correlation | Molecular axis |
|---|---|---|---|---|---|---|
circ-PVT1 | Upregulated | oncogene | Osteosarcoma | Resistance to doxorubicin and cisplatin | Enneking stage, lung metastasis, overall survival | circ-PVT1/ABCB1 |
hsa_circ_0004015 | Upregulated | oncogene | Non-small cell lung cancer | Resistance to gefitinib, Proliferation, colony-formation ability, invasion | Differentiation grade, tumor invasion, TNM stage | hsa_circ_0004015/miR-1183/PDPK1 |
circ_0006528 | Upregulated | oncogene | Breast cancer | Resistance to adriamycin, DNA synthesis, proliferation, invasion, migration, cell cycle, apoptosis | TNM stage, relapse-free survival, overall survival | circ_0006528/miR-7-5p/ Raf1/MEK/ERK |
hsa_circ_0000504 | Upregulated | / | Colorectal cancer | Resistance to 5-fluorouracil | / | hsa_circ_0000504/ hsa-miR-485-5p/STAT3 |
hsa_circ_0043632 | Upregulated | / | Non-small cell lung cancer | Resistance to EGFR-TKI inhibitor AZD9291 | / | hsa_circ_0043632/miR-492/ TIMP2 |
circ-MTO1 | Downregulated | / | Breast cancer | Resistance to monastrol, proliferation | / | circ-MTO1/TRAF4/Eg5 |
hsa-circ-0001258 | Downregulated | / | Osteosarcoma | Resistance to doxorubicin | / | hsa-circ-0001258/ hsa-miR-744-3p/GSTM2 |
CircPAN3 | / | / | AML | Resistance to doxorubicin | / | circPAN3/miR-153-5p / miR-183-5p-XIAP |