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Fig. 1 | Molecular Cancer

Fig. 1

From: Chemotherapeutic drugs stimulate the release and recycling of extracellular vesicles to assist cancer cells in developing an urgent chemoresistance

Fig. 1

Chemotherapeutic drug VCR stimulates the secretion of ABCB1-enriched EVs. A-B The stimulation of chemotherapeutic agent VCR on the EV release from the resistant KBv200 cells was showed. A Representive dot plots by flow cytometry. B Quantification of EVs. Horizontal lines represent the means from eight detections. C-D VCR promoted the EVs secretion in resistant KBv200 cells detected by flow cytometry with labeling FITC-conjugated Annexin V. E TEM images for EVs from VCR-untreated and treated KBv200 cells. F ABCB1 proteins were detected in EVs. G Sucrose density gradient centrifugation of EVs. H-I VCR obviously increases the extracellular ABCB1 protein level of KBv200 cells determined by Western blotting. Enzyme-linked immunoabsorbent assay (ELISA) shows VCR dose-dependently enhances the ABCB1 secretion in KBv200 cells

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