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Fig. 3 | Molecular Cancer

Fig. 3

From: Chemotherapeutic drugs stimulate the release and recycling of extracellular vesicles to assist cancer cells in developing an urgent chemoresistance

Fig. 3

Chemotherapeutic drugs strikingly facilitate the intercellular transfer of ABCB1. A The representative confocal images show the promotion of VCR on the intercellular transfer of ABCB1. Red represents Cy3-ABCB1 and green is GFP. B-C The effect of VCR on the intercellular transfer of ABCB1 is determined by flow cytometry. D The representative confocal images show the DDP-increased intercellular transfer of ABCB1. E-F The effect of DDP on the intercellular transfer of ABCB1 is determined by flow cytometry. G-H Aq-MDR cells acquire moderate surface expression levels of ABCB1. I-J Aq-MDR cells express high level of ABCB1 protein, but not mRNA. GAPDH is used as an internal control. Data represent the mean transfer rate ± S.D. * = P < 0.05, ** = P < 0.01

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Molecular Cancer

ISSN: 1476-4598