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Fig. 5 | Molecular Cancer

Fig. 5

From: Circular RNA MAPK4 (circ-MAPK4) inhibits cell apoptosis via MAPK signaling pathway by sponging miR-125a-3p in gliomas

Fig. 5

circ-MAPK4 acts as a sponge of miR-125a-3p in glioma cells. (a) Schematic illustration showing the overlap of target miRNAs of circ-MAPK4 predicted by RegRNA1.0, RNAhybrid and proved apoptosis relative miRNAs. (b) Predicted complementary binding sites between circ-MAPK4 and miRNAs. (c) qPCR were performed to evaluate expression levels of four predicted target miRNAs in circ-MAPK4 silenced U138 cells. (d) miRNAs were pulled down by the biotin labeled probe targeting to either random sequences or circ-MAPK4 black-splice junction sequence. Enrichment of the four predicted miRNAs was analyzed using qPCR. (E1ā€“4) Relatively differential expression levels of the four predicted miRNAs between glioma tissues and normal brain tissues were analyzed based on the TCGA data

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