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Fig. 5 | Molecular Cancer

Fig. 5

From: Circular RNA MAPK4 (circ-MAPK4) inhibits cell apoptosis via MAPK signaling pathway by sponging miR-125a-3p in gliomas

Fig. 5

circ-MAPK4 acts as a sponge of miR-125a-3p in glioma cells. (a) Schematic illustration showing the overlap of target miRNAs of circ-MAPK4 predicted by RegRNA1.0, RNAhybrid and proved apoptosis relative miRNAs. (b) Predicted complementary binding sites between circ-MAPK4 and miRNAs. (c) qPCR were performed to evaluate expression levels of four predicted target miRNAs in circ-MAPK4 silenced U138 cells. (d) miRNAs were pulled down by the biotin labeled probe targeting to either random sequences or circ-MAPK4 black-splice junction sequence. Enrichment of the four predicted miRNAs was analyzed using qPCR. (E1–4) Relatively differential expression levels of the four predicted miRNAs between glioma tissues and normal brain tissues were analyzed based on the TCGA data

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