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Table 1 Representative circRNAs and related signaling pathways in glioma

From: Functions and clinical significance of circular RNAs in glioma

circRNADysregulationSponge target/mechanismDownstream genes and signaling pathwayPhenotypeClinical significanceReferences
circPINTexon2downEncode PINT 87aaWork as an anchor of PAF1 complex and inhibit downstream genes CPEB1,SOX2,c-mycTumorigenicityWHO grade[31]
circHIPK3upmiR-654IGF2BP3Proliferation, invasionPrognostic biomarker[50]
hsa_circ_0076248upmiR-181aSIRT1Tumorigenesis
Apoptosis, invasion
TMZ sensitivity[52]
circ_0034642upmiR-1205BATF3Proliferation, migration,
invasion, apoptosis
Prognostic predictor[53]
circSMARCA5downSRSF1VEGFAMigration, angiogenesisWHO grade
Prognostic biomarker
[63]
circSHPRHdownEncode SHPRH-146aaProtect SHPRH which ubiquitinates PCNAProliferation, tumorigenicityPrognostic biomarker[69]
circFBXW7downEndode FBXW7-185aaReduced the half-life of c-Myc by antagonizing USP28-induced c-Myc stabilizationProliferation, cell cyclePrognostic biomarker[70]
circNFIXupmiR-34a-5pNotch1
Notch signaling
Proliferation, migration,
Invasion, apoptosis
/[77]
circHIPK3upmiR-124-3pSTAT3Proliferation, invasion,Prognostic biomarker[80]
circMMP9upmiR-124CDK4, AUPKAProliferation, migration,
Invasion
/[81]
CircNT5EupmiR-422aNT5E,SOX4,PI3K,P-AKT,
p-smad2
PI3K/AKT signaling
Smad2 signaling
Proliferation, migration,
invasion
/[82]
hsa_circ_0046701upmiR-142-3PITGB8Proliferation, invasion/[83]
has_circ_001946downmiR-671-5pCDR1Proliferation, migration,
Invasion, apoptosis
/[84]
hsa_circ_0012129upmiR-661/Proliferation, migration,
invasion
/[86]
cZNF292up/Wnt/β-catenin signaling and related genes including cyclinA,p-CDK2,VEGFR,
EGFR
Proliferation, cell cycle
angiogenesis
/[92]
hsa_circ_0000177upmiR-638FZD7
Wnt/β-catenin signaling
Proliferation, migration,
invasion
Prognosis biomarker[93]
circTTBK2upmiR-217HNF1β/Derlin1
PI3K/AKT and ERK signaling
Proliferation, migration,
Invasion, apoptosis
/[97]
hsa_circ_14359upmiR-153p-AKT
PI3K/AKT signaling
Proliferation, migration,
Invasion, apoptosis
/[98]
circU2AF1upmiR-7-5PNOVA2
PI3K/AKT and ERK signaling
Proliferation, migration,
Invasion, apoptosis
WHO grade[101]
circCFHupmiR-149AKT1
PI3K/AKT signaling
ProliferationWHO grade[102]
circSHKBP1upmiR-544a/miR379FOXP1/FOXP2/AGG1
PI3K/AKT and ERK signaling
Proliferation, migration,
angiogenesis
/[105]
has_circ_002136upmiR-138-5pSOX13/SPON2Migration, invasion angiogenesis/[107]
circDICER1upmiR-103a-3p
miR-382-5p
ZIC4/HSP90
PI3k/AKT signaling
Proliferation, migration,
angiogenesis
/[108]
has_circ_0074362upmiR-1236-3PHOXB7Proliferation, migration,
invasion
/[113]
cir-ITCHdownmiR-214ITCH/wnt/β-catenin signalingProliferation, migration,
invasion
Prognostic biomarker[114]
hsa_circ_0001649down/BCL2/caspase3 signalingApoptosisTumor size
WHO grade
Overall survival
[115]