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Table 1 Representative circRNAs and related signaling pathways in glioma

From: Functions and clinical significance of circular RNAs in glioma

circRNA Dysregulation Sponge target/mechanism Downstream genes and signaling pathway Phenotype Clinical significance References
circPINTexon2 down Encode PINT 87aa Work as an anchor of PAF1 complex and inhibit downstream genes CPEB1,SOX2,c-myc Tumorigenicity WHO grade [31]
circHIPK3 up miR-654 IGF2BP3 Proliferation, invasion Prognostic biomarker [50]
hsa_circ_0076248 up miR-181a SIRT1 Tumorigenesis
Apoptosis, invasion 		TMZ sensitivity [52]
circ_0034642 up miR-1205 BATF3 Proliferation, migration,
invasion, apoptosis 		Prognostic predictor [53]
circSMARCA5 down SRSF1 VEGFA Migration, angiogenesis WHO grade
Prognostic biomarker 		[63]
circSHPRH down Encode SHPRH-146aa Protect SHPRH which ubiquitinates PCNA Proliferation, tumorigenicity Prognostic biomarker [69]
circFBXW7 down Endode FBXW7-185aa Reduced the half-life of c-Myc by antagonizing USP28-induced c-Myc stabilization Proliferation, cell cycle Prognostic biomarker [70]
circNFIX up miR-34a-5p Notch1
Notch signaling 		Proliferation, migration,
Invasion, apoptosis 		/ [77]
circHIPK3 up miR-124-3p STAT3 Proliferation, invasion, Prognostic biomarker [80]
circMMP9 up miR-124 CDK4, AUPKA Proliferation, migration,
Invasion 		/ [81]
CircNT5E up miR-422a NT5E,SOX4,PI3K,P-AKT,
p-smad2
PI3K/AKT signaling
Smad2 signaling 		Proliferation, migration,
invasion 		/ [82]
hsa_circ_0046701 up miR-142-3P ITGB8 Proliferation, invasion / [83]
has_circ_001946 down miR-671-5p CDR1 Proliferation, migration,
Invasion, apoptosis 		/ [84]
hsa_circ_0012129 up miR-661 / Proliferation, migration,
invasion 		/ [86]
cZNF292 up / Wnt/β-catenin signaling and related genes including cyclinA,p-CDK2,VEGFR,
EGFR 		Proliferation, cell cycle
angiogenesis 		/ [92]
hsa_circ_0000177 up miR-638 FZD7
Wnt/β-catenin signaling 		Proliferation, migration,
invasion 		Prognosis biomarker [93]
circTTBK2 up miR-217 HNF1β/Derlin1
PI3K/AKT and ERK signaling 		Proliferation, migration,
Invasion, apoptosis 		/ [97]
hsa_circ_14359 up miR-153 p-AKT
PI3K/AKT signaling 		Proliferation, migration,
Invasion, apoptosis 		/ [98]
circU2AF1 up miR-7-5P NOVA2
PI3K/AKT and ERK signaling 		Proliferation, migration,
Invasion, apoptosis 		WHO grade [101]
circCFH up miR-149 AKT1
PI3K/AKT signaling 		Proliferation WHO grade [102]
circSHKBP1 up miR-544a/miR379 FOXP1/FOXP2/AGG1
PI3K/AKT and ERK signaling 		Proliferation, migration,
angiogenesis 		/ [105]
has_circ_002136 up miR-138-5p SOX13/SPON2 Migration, invasion angiogenesis / [107]
circDICER1 up miR-103a-3p
miR-382-5p 		ZIC4/HSP90
PI3k/AKT signaling 		Proliferation, migration,
angiogenesis 		/ [108]
has_circ_0074362 up miR-1236-3P HOXB7 Proliferation, migration,
invasion 		/ [113]
cir-ITCH down miR-214 ITCH/wnt/β-catenin signaling Proliferation, migration,
invasion 		Prognostic biomarker [114]
hsa_circ_0001649 down / BCL2/caspase3 signaling Apoptosis Tumor size
WHO grade
Overall survival 		[115]
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Molecular Cancer

ISSN: 1476-4598