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Table 1 Representative circRNAs and related signaling pathways in glioma

From: Functions and clinical significance of circular RNAs in glioma

circRNA

Dysregulation

Sponge target/mechanism

Downstream genes and signaling pathway

Phenotype

Clinical significance

References

circPINTexon2

down

Encode PINT 87aa

Work as an anchor of PAF1 complex and inhibit downstream genes CPEB1,SOX2,c-myc

Tumorigenicity

WHO grade

[31]

circHIPK3

up

miR-654

IGF2BP3

Proliferation, invasion

Prognostic biomarker

[50]

hsa_circ_0076248

up

miR-181a

SIRT1

Tumorigenesis

Apoptosis, invasion

TMZ sensitivity

[52]

circ_0034642

up

miR-1205

BATF3

Proliferation, migration,

invasion, apoptosis

Prognostic predictor

[53]

circSMARCA5

down

SRSF1

VEGFA

Migration, angiogenesis

WHO grade

Prognostic biomarker

[63]

circSHPRH

down

Encode SHPRH-146aa

Protect SHPRH which ubiquitinates PCNA

Proliferation, tumorigenicity

Prognostic biomarker

[69]

circFBXW7

down

Endode FBXW7-185aa

Reduced the half-life of c-Myc by antagonizing USP28-induced c-Myc stabilization

Proliferation, cell cycle

Prognostic biomarker

[70]

circNFIX

up

miR-34a-5p

Notch1

Notch signaling

Proliferation, migration,

Invasion, apoptosis

/

[77]

circHIPK3

up

miR-124-3p

STAT3

Proliferation, invasion,

Prognostic biomarker

[80]

circMMP9

up

miR-124

CDK4, AUPKA

Proliferation, migration,

Invasion

/

[81]

CircNT5E

up

miR-422a

NT5E,SOX4,PI3K,P-AKT,

p-smad2

PI3K/AKT signaling

Smad2 signaling

Proliferation, migration,

invasion

/

[82]

hsa_circ_0046701

up

miR-142-3P

ITGB8

Proliferation, invasion

/

[83]

has_circ_001946

down

miR-671-5p

CDR1

Proliferation, migration,

Invasion, apoptosis

/

[84]

hsa_circ_0012129

up

miR-661

/

Proliferation, migration,

invasion

/

[86]

cZNF292

up

/

Wnt/β-catenin signaling and related genes including cyclinA,p-CDK2,VEGFR,

EGFR

Proliferation, cell cycle

angiogenesis

/

[92]

hsa_circ_0000177

up

miR-638

FZD7

Wnt/β-catenin signaling

Proliferation, migration,

invasion

Prognosis biomarker

[93]

circTTBK2

up

miR-217

HNF1β/Derlin1

PI3K/AKT and ERK signaling

Proliferation, migration,

Invasion, apoptosis

/

[97]

hsa_circ_14359

up

miR-153

p-AKT

PI3K/AKT signaling

Proliferation, migration,

Invasion, apoptosis

/

[98]

circU2AF1

up

miR-7-5P

NOVA2

PI3K/AKT and ERK signaling

Proliferation, migration,

Invasion, apoptosis

WHO grade

[101]

circCFH

up

miR-149

AKT1

PI3K/AKT signaling

Proliferation

WHO grade

[102]

circSHKBP1

up

miR-544a/miR379

FOXP1/FOXP2/AGG1

PI3K/AKT and ERK signaling

Proliferation, migration,

angiogenesis

/

[105]

has_circ_002136

up

miR-138-5p

SOX13/SPON2

Migration, invasion angiogenesis

/

[107]

circDICER1

up

miR-103a-3p

miR-382-5p

ZIC4/HSP90

PI3k/AKT signaling

Proliferation, migration,

angiogenesis

/

[108]

has_circ_0074362

up

miR-1236-3P

HOXB7

Proliferation, migration,

invasion

/

[113]

cir-ITCH

down

miR-214

ITCH/wnt/β-catenin signaling

Proliferation, migration,

invasion

Prognostic biomarker

[114]

hsa_circ_0001649

down

/

BCL2/caspase3 signaling

Apoptosis

Tumor size

WHO grade

Overall survival

[115]