Table 1 Representative circRNAs and related signaling pathways in glioma
From: Functions and clinical significance of circular RNAs in glioma
| circRNA | Dysregulation | Sponge target/mechanism | Downstream genes and signaling pathway | Phenotype | Clinical significance | References |
|---|---|---|---|---|---|---|
| circPINTexon2 | down | Encode PINT 87aa | Work as an anchor of PAF1 complex and inhibit downstream genes CPEB1,SOX2,c-myc | Tumorigenicity | WHO grade | [31] |
| circHIPK3 | up | miR-654 | IGF2BP3 | Proliferation, invasion | Prognostic biomarker | [50] |
| hsa_circ_0076248 | up | miR-181a | SIRT1 | Tumorigenesis Apoptosis, invasion | TMZ sensitivity | [52] |
| circ_0034642 | up | miR-1205 | BATF3 | Proliferation, migration, invasion, apoptosis | Prognostic predictor | [53] |
| circSMARCA5 | down | SRSF1 | VEGFA | Migration, angiogenesis | WHO grade Prognostic biomarker | [63] |
| circSHPRH | down | Encode SHPRH-146aa | Protect SHPRH which ubiquitinates PCNA | Proliferation, tumorigenicity | Prognostic biomarker | [69] |
| circFBXW7 | down | Endode FBXW7-185aa | Reduced the half-life of c-Myc by antagonizing USP28-induced c-Myc stabilization | Proliferation, cell cycle | Prognostic biomarker | [70] |
| circNFIX | up | miR-34a-5p | Notch1 Notch signaling | Proliferation, migration, Invasion, apoptosis | / | [77] |
| circHIPK3 | up | miR-124-3p | STAT3 | Proliferation, invasion, | Prognostic biomarker | [80] |
| circMMP9 | up | miR-124 | CDK4, AUPKA | Proliferation, migration, Invasion | / | [81] |
| CircNT5E | up | miR-422a | NT5E,SOX4,PI3K,P-AKT, p-smad2 PI3K/AKT signaling Smad2 signaling | Proliferation, migration, invasion | / | [82] |
| hsa_circ_0046701 | up | miR-142-3P | ITGB8 | Proliferation, invasion | / | [83] |
| has_circ_001946 | down | miR-671-5p | CDR1 | Proliferation, migration, Invasion, apoptosis | / | [84] |
| hsa_circ_0012129 | up | miR-661 | / | Proliferation, migration, invasion | / | [86] |
| cZNF292 | up | / | Wnt/β-catenin signaling and related genes including cyclinA,p-CDK2,VEGFR, EGFR | Proliferation, cell cycle angiogenesis | / | [92] |
| hsa_circ_0000177 | up | miR-638 | FZD7 Wnt/β-catenin signaling | Proliferation, migration, invasion | Prognosis biomarker | [93] |
| circTTBK2 | up | miR-217 | HNF1β/Derlin1 PI3K/AKT and ERK signaling | Proliferation, migration, Invasion, apoptosis | / | [97] |
| hsa_circ_14359 | up | miR-153 | p-AKT PI3K/AKT signaling | Proliferation, migration, Invasion, apoptosis | / | [98] |
| circU2AF1 | up | miR-7-5P | NOVA2 PI3K/AKT and ERK signaling | Proliferation, migration, Invasion, apoptosis | WHO grade | [101] |
| circCFH | up | miR-149 | AKT1 PI3K/AKT signaling | Proliferation | WHO grade | [102] |
| circSHKBP1 | up | miR-544a/miR379 | FOXP1/FOXP2/AGG1 PI3K/AKT and ERK signaling | Proliferation, migration, angiogenesis | / | [105] |
| has_circ_002136 | up | miR-138-5p | SOX13/SPON2 | Migration, invasion angiogenesis | / | [107] |
| circDICER1 | up | miR-103a-3p miR-382-5p | ZIC4/HSP90 PI3k/AKT signaling | Proliferation, migration, angiogenesis | / | [108] |
| has_circ_0074362 | up | miR-1236-3P | HOXB7 | Proliferation, migration, invasion | / | [113] |
| cir-ITCH | down | miR-214 | ITCH/wnt/β-catenin signaling | Proliferation, migration, invasion | Prognostic biomarker | [114] |
| hsa_circ_0001649 | down | / | BCL2/caspase3 signaling | Apoptosis | Tumor size WHO grade Overall survival | [115] |