From: Functions and clinical significance of circular RNAs in glioma
circRNA | Dysregulation | Sponge target/mechanism | Downstream genes and signaling pathway | Phenotype | Clinical significance | References |
---|---|---|---|---|---|---|
circPINTexon2 | down | Encode PINT 87aa | Work as an anchor of PAF1 complex and inhibit downstream genes CPEB1,SOX2,c-myc | Tumorigenicity | WHO grade | [31] |
circHIPK3 | up | miR-654 | IGF2BP3 | Proliferation, invasion | Prognostic biomarker | [50] |
hsa_circ_0076248 | up | miR-181a | SIRT1 |
Tumorigenesis Apoptosis, invasion | TMZ sensitivity | [52] |
circ_0034642 | up | miR-1205 | BATF3 |
Proliferation, migration, invasion, apoptosis | Prognostic predictor | [53] |
circSMARCA5 | down | SRSF1 | VEGFA | Migration, angiogenesis |
WHO grade Prognostic biomarker | [63] |
circSHPRH | down | Encode SHPRH-146aa | Protect SHPRH which ubiquitinates PCNA | Proliferation, tumorigenicity | Prognostic biomarker | [69] |
circFBXW7 | down | Endode FBXW7-185aa | Reduced the half-life of c-Myc by antagonizing USP28-induced c-Myc stabilization | Proliferation, cell cycle | Prognostic biomarker | [70] |
circNFIX | up | miR-34a-5p |
Notch1 Notch signaling |
Proliferation, migration, Invasion, apoptosis | / | [77] |
circHIPK3 | up | miR-124-3p | STAT3 | Proliferation, invasion, | Prognostic biomarker | [80] |
circMMP9 | up | miR-124 | CDK4, AUPKA |
Proliferation, migration, Invasion | / | [81] |
CircNT5E | up | miR-422a |
NT5E,SOX4,PI3K,P-AKT, p-smad2 PI3K/AKT signaling Smad2 signaling |
Proliferation, migration, invasion | / | [82] |
hsa_circ_0046701 | up | miR-142-3P | ITGB8 | Proliferation, invasion | / | [83] |
has_circ_001946 | down | miR-671-5p | CDR1 |
Proliferation, migration, Invasion, apoptosis | / | [84] |
hsa_circ_0012129 | up | miR-661 | / |
Proliferation, migration, invasion | / | [86] |
cZNF292 | up | / |
Wnt/β-catenin signaling and related genes including cyclinA,p-CDK2,VEGFR, EGFR |
Proliferation, cell cycle angiogenesis | / | [92] |
hsa_circ_0000177 | up | miR-638 |
FZD7 Wnt/β-catenin signaling |
Proliferation, migration, invasion | Prognosis biomarker | [93] |
circTTBK2 | up | miR-217 |
HNF1β/Derlin1 PI3K/AKT and ERK signaling |
Proliferation, migration, Invasion, apoptosis | / | [97] |
hsa_circ_14359 | up | miR-153 |
p-AKT PI3K/AKT signaling |
Proliferation, migration, Invasion, apoptosis | / | [98] |
circU2AF1 | up | miR-7-5P |
NOVA2 PI3K/AKT and ERK signaling |
Proliferation, migration, Invasion, apoptosis | WHO grade | [101] |
circCFH | up | miR-149 |
AKT1 PI3K/AKT signaling | Proliferation | WHO grade | [102] |
circSHKBP1 | up | miR-544a/miR379 |
FOXP1/FOXP2/AGG1 PI3K/AKT and ERK signaling |
Proliferation, migration, angiogenesis | / | [105] |
has_circ_002136 | up | miR-138-5p | SOX13/SPON2 | Migration, invasion angiogenesis | / | [107] |
circDICER1 | up |
miR-103a-3p miR-382-5p |
ZIC4/HSP90 PI3k/AKT signaling |
Proliferation, migration, angiogenesis | / | [108] |
has_circ_0074362 | up | miR-1236-3P | HOXB7 |
Proliferation, migration, invasion | / | [113] |
cir-ITCH | down | miR-214 | ITCH/wnt/β-catenin signaling |
Proliferation, migration, invasion | Prognostic biomarker | [114] |
hsa_circ_0001649 | down | / | BCL2/caspase3 signaling | Apoptosis |
Tumor size WHO grade Overall survival | [115] |