Fig. 7
From: Hypoxia induced LUCAT1/PTBP1 axis modulates cancer cell viability and chemotherapy response
High LUCAT1 is associated with worse prognosis and poor response to chemotherapeutic drugs. a The expression of LUCAT1 in 97 paired CRC and adjacent normal (NT) tissues. n = 97 in CRC cohort, paired and unpaired Student’s t-test. b Kaplan–Meier analysis of overall survival curve in CRC patients with high LUCAT1 expression versus low LUCAT1 expression. n = 97 in CRC cohort. c The expression of LUCAT1 and HIF-1α in NACT cohort, and the correlation between LUCAT1 and HIF-1α in this cohort. n = 71 in NACT cohort, paired Student’s t-test and pearson correlation. d The association between tumor regression grade and HIF-1α or LUCAT1 in the NACT cohort. n = 78 in NACT cohort, Chi-squared test. e Kaplan–Meier analysis of overall survival or disease free survival curve in COAD patients with high LUCAT1 expression versus low LUCAT1 expression from TCGA cohort. Graphs were obtained from GEPIA (http://gepia.cancer-pku.cn/). f The expression of LUCAT1 in COAD patients with complete or partial response to drugs from TCGA cohort. n = 82 in TCGA-COAD, two-tailed Student’s t-test. g The graphic illustration demonstrating HIF-1α induced LUCAT1/PTBP1 axis in cancer