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Fig. 7 | Molecular Cancer

Fig. 7

From: A novel IFNα-induced long noncoding RNA negatively regulates immunosuppression by interrupting H3K27 acetylation in head and neck squamous cell carcinoma

Fig. 7

Overexpression of lncMX1–215 suppresses HNSCC metastasis. a, b Migration and invasion assays were performed with transfected cells using Transwell inserts (bar = 100 μm, 20 μm, respectively). c snail was detected in HN4 and Cal27 cells after transfection with lncMX1–215 or ASO for 48 h. d Representative images of lungs from mice in each experimental group. The arrows indicate individual metastatic nodules. Metastatic tumors in lung tissues were identified via hematoxylin and eosin staining. e The number of metastatic nodules in each group was analyzed. f Schematic diagram showing that IFNα-induced lncMX1–215 can negatively regulate PD-L1 and galectin-9 expression by interrupting GCN5/H3K27ac binding in HNSCC. *: P < 0.05; **: P < 0.01

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Molecular Cancer

ISSN: 1476-4598