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Table 1 SPOP plays a role in several types of human malignancies by targeting its downstream substrates

From: The emerging role of SPOP protein in tumorigenesis and cancer therapy

Cancer typePhysiological evidence (animal models)Pathological evidence (human cancer specimens)Biochemical evidence (downstream ubiquitin substrates)FunctionsRef
BCN/AMutation, reduced expressionc-Myc, SRC-3, PRSuppression of tumorigenesis[25,26,27]
CCN/AIncreased expression, deletion mutantNoneSuppression of CC tumorigenesis[28]
CRCN/AMutation, reduced expressionGli2, HDAC6Inhibition of proliferation and migration, promotion of apoptosis and inhibition of tumorigenesis[29,30,31]
ECConditional knockout SPOP–/–; infertility phenotype with reduction in PRs in the uterusMutation, reduced expressionBRD2, BRD3, BRD4, ERαInhibition of growth, suppression of EC tumorigenesis, enhanced sensitivity to BET inhibitors[32,33,34,35,36]
GCN/ADecreased expressionGli2Inhibition of proliferation, migration and GC tumorigenesis[37]
GliomaN/ASNPs, reduced expressionNoneSuppression of glioma tumorigenesis[38, 39]
HCCSubcutaneous tumor model (SPOP-overexpression; tumor suppressive role)Mutation, decreased expressionSENP7Inhibition of migration and invasion, and HCC tumorigenesis[40,41,42]
KCInjection with transfected HEK293 cells (SPOP-cyto, tumorigenesis)OverexpressionDaxx, DUSP7, Gli2, PTENInhibition of cell apoptosis, promotion of cell proliferation and ccRCC tumorigenesis.[43,44,45,46]
LCN/ADecreased expressionFADD, SIRT2Inhibition of growth, suppression of LC tumorigenesis[47, 48]
OCN/ADeletion mutantNoneSuppression of OC tumorigenesis[49, 50]
OSN/ADecreased expressionNoneSuppression of OS tumorigenesis[51]
PrCaTransgenic (expressing SPOP mutants); conditional knockout SPOP−/−); systemic knockout (embryonic lethal)Mutation, decreased expression.AR, ATF2, BRD4, cdc20, c-Myc, cyclin E1, DEK, EgIN2, ERG, PD-L1, SENP7, SRC-3, TRIM24.Inhibition of PrCa development and progression[52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76]
TCN/AMutationNoneSuppression of TC tumorigenesis[77,78,79]