Roles | CircRNAs | Origin | Expression | Functions | Targets | References |
---|---|---|---|---|---|---|
mediating tumour immune surveillance | circRNAs | exogenous | - | probably activated antitumour immunity | RIG-I/ immunocytes | [65] |
circRNAs | exosomes | - | probably regulated antitumour immunity | immunocytes | ||
circ-0020397 | CRC | up | inhibited the activation and proliferation of T cells, and promoted the viability and invasion of CRC cells | miR-138/ PD-L1 | [79] | |
circARSP91 | HCC | up | enhanced the cytotoxicity of NK cell and upregulated NK-mediated immune responses | ULBP1 | [92] | |
circ-0000977 | PC | - | inhibited the killing ability of NK | miR-153 /HIF1α, ADAM10 | [168] | |
promoting angiogenesis | circ0001429 | bladder cancer | up | promoted cell metastasis and angiogenesis | miR-205-5p /VEGFA | [99] |
circSCAF11 | glioma | up | stimulated angiogenesis and tumourigenesis | miR-421/SP1/ VEGFA | [100] | |
circRNA cZNF292 | glioma | up | promoted cell proliferation and angiogenesis | VEGFR-1/2, p-VEGFR-1/2 and EGFR | [101] | |
circRNA cZNF292 | hepatoma | up | promoting cell proliferation, VM, and radioresistance | SOX9, Wnt/β-catenin | [103] | |
circ-SHKBP1I | GECs | up | stimulated angiogenesis | miR-544a/ FOXP1/ AGGF1 or miR-379/ FOXP2/ AGGF1 | [20] | |
circ-0010729 | HUVECs | up | promoted vascular endothelial cell proliferation | miR-186 /HIF1α | [104] | |
circ-002136 | GECs | up | stimulated angiogenesis | FUS/circ-002136 /miR-138-5p /SOX13 feedback loop | [105] | |
circ-DICER1 | GECs | up | promoted angiogenesis | MOV10/circ-DICER1 /miR-103a-3p (miR-382-5p) /ZIC4 Hsp90β/PI3K/Akt | [106] | |
inhibiting angiogenesis | circHIPK3 | bladder cancer | down | inhibited cell migration, invasion, and angiogenesis | miR-558/ HPSE/ MMP-9 and VEGF | [107] |
circSMARCA5 | GBM | down | inhibited angiogenesis | VEGFA, SRSF1 | Â | |
circ-0003575 | HUVECs | up | inhibiting angiogenesis | potential circRNA-miRNA-mRNA network | [110] | |
improving endothelial cell permeability | circRNA IARS | exosomes derived from PC cells | up | enhanced cell invasion, metastasis and endothelial cell permeability | miR-122/ RhoA/ F-actin | [112] |
hypoxia | circDENND4C | breast cancer | up | promoted cell proliferation | - | Â |
circDENND4C | breast cancer | up | promoted cell glycolysis, migration, invasion and proliferation | miR-200b and miR-200c | [116] | |
circDENND2A | glioma | up | promoted cell migration and invasion | miR-625-5p | [169] | |
circ-0000977 | PC | - | mediated immune escape | miR-153/ HIF1α | [168] | |
circ-0010729 | HUVECs | up | enhanced cell proliferation, migration and suppressed apoptosis | miR-186/ HIF1α | [104] | |
circRNA cZNF292 | hepatoma | up | promoted cell proliferation, VM, and radioresistance | SOX9, Wnt/β-catenin | [103] | |
causing ECM remodelling | circ-0000096 | gastric cancer | down | affected cell growth and migration | VEGF, MMP-2 and MMP-9 | [120] |
circLMNB1 | CRC | up | promoted cell dissemination, invasion and EMT | MMP-2 and MMP-9 | [121] | |
circDENND4C | breast cancer | up | suppressed cell migration and invasion | MMP-2 and MMP-9 | [116] | |
circ-0007334 | PDAC | up | promoted cell invasion | miR-144-3p and miR-577/ COL1A1, MMP-7 | [122] | |
circRNA cSMARCA5 | HCC | down | inhibited cell proliferation and migration | miRNA-17-3p and miRNA-181b-5p/ TIMP-3 | [124] | |
exosomes | circRNA IARS | exosomes derived from PC cells | up | promotedcell invasion and metastasis | miR-122 | [112] |
circ-DB | exosomes derived from adipocytes | up | promoted tumourigenesis and metastasis of HCC | miR-34a/ USP7/ cyclin A2 | [135] | |
ciRS-133 (circ-0010522) | exosomes derived from GC cells | up | promoted white adipose browning in patients with gastric cancer | miR-133/ PRDM16 | [119] |