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Fig. 3 | Molecular Cancer

Fig. 3

From: Circular RNA CRIM1 functions as a ceRNA to promote nasopharyngeal carcinoma metastasis and docetaxel chemoresistance through upregulating FOXQ1

Fig. 3

FOXQ1 is a direct target of miR-422a and is involved in circCRIM1-associated NPC metastasis and chemoresistance. a Schematic of the predicted miR-422a binding site in the FOXQ1 3′ UTR. b Luciferase activity of wild type or mutated FOXQ1 3′ UTR in NPC cells after cotransfection with miR-422a or control. c-d qRT-PCR (c) and Western blotting (d) of FOXQ1 expression in NPC cells with or without miR-422a overexpression. e Docetaxel resistance-related biological functions were enriched in response to high FOXQ1 expression (GSE12452). f-g Dose-response curves (f) and representative and quantified results (g) for docetaxel treatment in S18 and HONE1 cells with or without circCRIM1 downregulation. The cells were treated with low-dose docetaxel. The error bars represent the mean (n = 3) ± S.D. Student’s t-test; *P < 0.05

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