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Fig. 5 | Molecular Cancer

Fig. 5

From: Circular RNA CRIM1 functions as a ceRNA to promote nasopharyngeal carcinoma metastasis and docetaxel chemoresistance through upregulating FOXQ1

Fig. 5

CircCRIM1 promotes NPC cell metastasis in vivo. a S18 cells were inoculated into mouse footpads. Representative images of footpad tumors after cholesterol-conjugated circCRIM1 siRNA or siSCR injection. b Representative microscopy images of footpad tumors. Scale bar, 100 μm. c Representative image and quantification of the volumes of the inguinal lymph nodes. Mean (n = 8) ± S.D. Student’s t-tests; *P < 0.05. d Representative images of pan-cytokeratin positive inguinal lymph nodes and metastatic ratios. Scale bar, 100 μm. Inguinal lymph node metastatic ratios. Chi-square test.; *P < 0.05. e-f Representative images and quantification of macroscopic (e) and microscopic metastatic nodules (f) in the lungs of mice after systemic administration of cholesterol-conjugated circCRIM1 siRNA or NC control via tail vein injection. Mean (n = 5) ± S.D. Student’s t-test, *P < 0.05. Scale bar, 100 μm. g Representative images of immunohistochemical staining for FOXQ1 expression and relative circCRIM1 expressions in the lungs of mice. Scale bar, 100 μm. Mean (n = 5) ± S.D. Student’s t-test, *P < 0.05

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Molecular Cancer

ISSN: 1476-4598