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Fig. 2 | Molecular Cancer

Fig. 2

From: Autophagy-associated circRNA circCDYL augments autophagy and promotes breast cancer progression

Fig. 2

Clinical significance of circCDYL in breast cancer. a Comparison of circCDYL expression between breast cancer tissues and paired adjacent non-cancerous tissues by qRT-PCR (n = 47) and their representative images by ISH. Scale bar = 50 μm. b Correlations of circCDYL expression and the number of LC3 dots in breast cancer tumors, analyzed by Pearson analysis. c Representative images of LC3 dots and circCDYL expression by ISH in breast cancer tissues (left) and quantitative analysis of circCDYL expression in cancer tissues with more and less LC3 dots. Scale bar = 50 μm. d Kaplan-Meier analysis of the correlation between circCDYL expression and disease-free survival (DFS). e circCDYL abundance in serum of patients detected by ddPCR (n = 62, Cohort 2). EBC: early breast cancer, MBC: metastatic breast cancer.f Representative images in cases with lung and liver metastasis before and after chemotherapy and real time kinetics of serum circCDYL during chemotherapy in MBC patients (n = 18, Cohort 2). PR: partial response; CR: complete response; PD: progressive disease; SD: stable disease. g Kaplan-Meier analysis of the correlation between serum circCDYL expression and overall survival (OS) in MBC patients (Cohort 3). *P <  0.05, **P < 0.01, ***P < 0.005. Error bars indicate Standard Error of Mean (S.E.M)

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