TY - JOUR AU - Wu, Yuqing AU - Zhang, Siwei AU - Gong, Xiaoxiao AU - Tam, Samantha AU - Xiao, Desheng AU - Liu, Shuang AU - Tao, Yongguang PY - 2020 DA - 2020/02/27 TI - The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression JO - Molecular Cancer SP - 39 VL - 19 IS - 1 AB - Ferroptosis, a novel form of regulated cell death, is different from other types of cell death in morphology, genetics and biochemistry. Increasing evidence indicates that ferroptosis has significant implications on cell death linked to cardiomyopathy, tumorigenesis, and cerebral hemorrhage to name a few. Here we summarize current literature on ferroptosis, including organelle dysfunction, signaling transduction pathways, metabolic reprogramming and epigenetic regulators in cancer progression. With regard to organelles, mitochondria-induced cysteine starvation, endoplasmic reticulum-related oxidative stress, lysosome dysfunction and golgi stress-related lipid peroxidation all contribute to induction of ferroptosis. Understanding the underlying mechanism in ferroptosis could provide insight into the treatment of various intractable diseases including cancers. SN - 1476-4598 UR - https://doi.org/10.1186/s12943-020-01157-x DO - 10.1186/s12943-020-01157-x ID - Wu2020 ER -