Fig. 3
From: The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression
The epigenetic regulators in ferroptosis. The BAP1-mediated pathway independent of TP53 executes the suppression of SLC7A11. LSH expression is up-regulated by c-Myc, which is enriched at the LSH promoter by the EGLN1-mediated repression of HIF-1α. The induced LSH interacts with WDR76, which, in turn, up-regulates the lipid metabolic genes including SCD1 and FADS2. LSH also induces ELAVL1 expression through the inactivation of p53 and ELAVL1, enhancing LINC00336 levels. LINC00336 serves as an endogenous sponge of MIR6852 as a circulating extracellular DNA (ceRNA), which increases the mRNA levels of CBS, inhibiting ferroptosis in lung cancer. P53RRA promotes ferroptosis by retaining p53 in the nucleus