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Fig. 2 | Molecular Cancer

Fig. 2

From: RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner

Fig. 2

ALKBH5 effects on the transcription profile of PC cells. a A volcano plot shows the statistically upregulated (red) and downregulated (green) genes between BxPC-3/vector cells (Control) and BxPC-3/Lv-ALKBH5 cells (ALKBH5 overexpression). b Heatmap exhibits the top 15 upregulated genes between BxPC-3/vector c and BxPC-3/Lv-ALKBH5 (OE) cells. C: Control group; OE: Overexpression group. c, d Gene ontologies (GOs) related to the upregulated c and downregulated genes d reflected an enrichment of processes concerning cell cycle, apoptosis, and proliferation. e, f Signalling pathways related to the upregulated (e) and downregulated genes f uncovered a role for differentially expressed genes in signal transduction

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